Results 61 to 70 of about 3,928,365 (313)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Political Theory, Political Science, And The End Of Civic Engagement [PDF]

, 2009
Within a span of fifteen years civic engagement has become a cottage industry in political science and political theory, but the term has now outlived its usefulness and exemplifies Giovanni Sartori\u27s worry about conceptual stretching.
Arendt, Arendt, Arendt, Arendt, Arendt, Arendt, Arendt, Barber, Barber, Ben Berger, Bennett, Berman, Bloom, Brown, Chambers, Cohen, Durkheim, Ehrenhalt, Feinberg, Gans, Gough, Havel, Hicks, Hont, Irwin, James, Jones, Kateb, King, King, Kornhauser, Ladd, Ladd, Levinger, Levinson, Lord, Maimonides, Marx, McGann, Norris, Oldenburg, Pateman, Pitkin, Putnam, Putnam, Rosenblum, Rosenstone, Sandel, Schudson, Sennett, Shaftesbury, Shklar, Shumer, Skocpol, Taylor, Tocqueville, Tocqueville, Tönnies, Valelly, Verba, Warren, Wuthnow   +61 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Effectively Engaging Diasporas Under the New Canadian Department of Foreign Affairs, Trade and Development [PDF]

, 2013
With the amalgamation of the Canadian International Development Agency (CIDA) and the Department of Foreign Affairs and International Trade (DFAIT) into a new Department of Foreign Affairs, Trade and Development (DFATD), new opportunities will emerge for
Chanoine, Manuelle, Giel, Meredith, Simão, Tâmara   +2 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Early experiences as intrinsic, extrinsic, and interpersonal motivators that influence first year medical school students’ career choice for medicine: a qualitative study

Discover Education
Background Research is needed to better understand the early experiences that motivate and influence students to choose careers in medicine. Methods We addressed this research gap with an exploratory qualitative study that included four focus groups ...
Jessica St. Louis, Megan Pasquantonio-Pierce, Emorcia V. Hill, Joan Y. Reede, Jeffrey N. Katz   +4 more
doaj   +1 more source

Fostering Inquiry: The Impact of Cross-Curricular Professional Development on STEM Teacher Practices

Education Sciences
This study investigated the impact of sustained, inquiry-based professional development (PD) on K-12 STEM educators’ instructional practices, with a particular focus on integrated mathematics and science teaching.
Mirna Mendoza Wilson, Faiza Zafar, Carolyn Nichol   +2 more
doaj   +1 more source

Staff Engagement for Cohesion [PDF]

, 2016
This chapter in a book on small and rural libraries looks at issues around why staff engagement is a concern. We discuss the barriers to staff engagement and the role professional development plays in lowering the barriers.
Ward, Jennifer, Wilkes, Bethany
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source