Results 121 to 130 of about 25,670,789 (354)

Predictions and measurements of spark-ignition engine characteristics using ammonia and other fuels

, 1988
PhDThe project reported here involves the development of a computer model for determining the characteristics of a spark-ignition engine. The model incorporates detailed consideration of the combustion process -and includes calculations for heat ...
Mozafari-Varnusfadrani, Aliasghar
core  

Diesel engine heat release analysis by using newly defined dimensionless parameters [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosphy and awarded by Brunel UniversityDiesel engine combustion has been studied during the last decades by researchers in terms of improving the performance of the engine.
Abbaszadehmosayebi, Gholamreza
core  

Treatment effects in epilepsy: a mathematical framework for understanding response over time

Frontiers in Network Physiology
Epilepsy is a neurological disorder characterized by recurrent seizures, affecting over 65 million people worldwide. Treatment typically commences with the use of anti-seizure medications, including both mono- and poly-therapy.
Elanor G. Harrington, Elanor G. Harrington, Peter Kissack, Peter Kissack, John R. Terry, John R. Terry, Wessel Woldman, Wessel Woldman, Leandro Junges   +8 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Identifying improvements to the engine assembly line simulation philosophies within Ford Motor Company [PDF]

, 2006
Ford Motor Company (Ford) utilise unique simulation models to represent the behaviour of their diesel engine assembly lines. The simulation model is a computerised tool used to support modification decisions that affect the assembly processes and ...
Dewson, Philip
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

In-Situ Monitoring of Directed Energy Deposition Laser Beam of Nickel-Based Superalloy via Built-in Optical Coaxial Camera

Sensors
This study presents the development and validation of an in situ monitoring method for the laser direct energy deposition (DED) process, utilizing an integrated optical camera (720 HD, 60 fps) to analyze melt pool imagery.
Rustam Paringer, Aleksandr Khaimovich, Vadim Pechenin, Andrey Balyakin   +3 more
doaj   +1 more source