Results 111 to 120 of about 965,816 (315)
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
DEAN: A program for dynamic engine analysis [PDF]
The Dynamic Engine Analysis program, DEAN, is a FORTRAN code implemented on the IBM/370 mainframe at NASA Lewis Research Center for digital simulation of turbofan engine dynamics.
Melcher, K. J., Sadler, G. G.
core +1 more source
Assessing the Effectiveness and Usability of Personalized Internet Search through a Longitudinal Evaluation [PDF]
, 2009 This paper discusses a longitudinal user evaluation of Prospector, a personalized Internet meta-search engine capable of personalized re-ranking of search results. Twenty-one participants used Prospector as their primary search engine for 12 days, agreed
König, Florian +2 more
core +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Treatment effects in epilepsy: a mathematical framework for understanding response over time
Frontiers in Network PhysiologyEpilepsy is a neurological disorder characterized by recurrent seizures, affecting over 65 million people worldwide. Treatment typically commences with the use of anti-seizure medications, including both mono- and poly-therapy.
Elanor G. Harrington +8 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
The JT8D and JT9D engine component improvement: Performance improvement program [PDF]
The NASA sponsored Engine Component Improvement - Performance Improvement Program at Pratt & Whitney Aircraft advanced the state of the art of thermal barrier coatings and ceramic seal systems, demonstrated the practicality of an advanced turbine ...
Gaffin, W. O.
core +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Real-time in-flight engine performance and health monitoring techniques for flight research application [PDF]
Procedures for real time evaluation of the inflight health and performance of gas turbine engines and related systems were developed to enhance flight test safety and productivity. These techniques include the monitoring of the engine, the engine control
Hicks, John W. +2 more
core +1 more source