Results 91 to 100 of about 25,670,789 (354)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Simulation of a diesel engine for testing monitoring systems
, 2008 This report describes the development of a mathematical model of a mechanically controlled diesel engine for the purpose of implementing an engine simulator.
Benson, Michael John
core
Improvement and validation of a thermodynamic S.I. engine simulation code [PDF]
, 2003 This study was concerned with improvement and validation of a thermodynamic spark ignition engine simulation code developed in Leeds. Experimental validation data were generated using a central ignition, disc-shaped combustion chamber variant of a ...
Abdi Aghdam, Ebrahim
core
METHOD OF CONVERSION OF HIGH- AND MIDDLE-SPEED DIESEL ENGINES INTO GAS DIESEL ENGINES
Facta Universitatis. Series: Mechanical Engineering, 2017 The paper aims at the development of fuel supply and electronic control systems for boosted high- and middle-speed transport engines. A detailed analysis of different ways of converting diesel engine to operate on natural gas was carried out.
Mikhail G. Shatrov +4 more
doaj +1 more source
Experimental characterization of autonomous heat engine based on minimal dynamical-system model
Physical Review Research, 2020 The autonomous heat engine is a model system of autonomous nonequilibrium systems, exploiting nonequilibrium flow for operations. As the Carnot engine has essentially contributed to the equilibrium thermodynamics, an autonomous heat engine is expected to
Shoichi Toyabe, Yuki Izumida
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
In-cylinder fuel and lubricant effects on gasoline engine friction [PDF]
, 2007 The purpose of the research reported in this thesis was to investigate the viability and quantify the potential gains of improving fuel economy of the gasoline engine through strategic application of additives.
Smith, Oiver Mark Edward +1 more
core
, 2012 In this paper, an experimental investigation has been carried out on the acoustic characteristics of a compression ignition (CI) engine running with biodiesel blends under steady state operating conditions. The experiment was conducted on a four-cylinder,
Gu, Fengshou +9 more
core +1 more source