Results 91 to 100 of about 9,909,879 (292)
Engineering complex systems [PDF]
Nature, 2004 The emergent properties of complex systems are far removed from the traditional preoccupation of engineers with design and purpose.
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
IET Collaborative Intelligent ManufacturingIn human‐centric smart manufacturing (HCSM), the robot's dynamic obstacle avoidance function is crucial to ensuring human safety. Unlike the static obstacle avoidance of manipulators or mobile robots, the dynamic obstacle avoidance in mobile manipulators
Yong Tao +6 more
doaj +1 more source
Journal of Materials Research and TechnologyShell/core integral mold fabricated by additive manufacturing possess high shell/core bonding strength, which is promising to improve the dimensional accuracy and integrity of single-crystal (SX) hollow blade while improving the manufacturing efficiency.
Binqiang Wang +7 more
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Journal of the Global Power and Propulsion Society, 2017 The thermal performance of two cavity-winglet tips with endwall motion is investigated in a transonic high pressure turbine cascade, which operates at an engine representative exit Mach number of 1.2 and an exit Reynolds number of 1.7 × 106.
Fangpan Zhong, Chao Zhou
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Energy and AIThe poppet valves two-stroke (PV2S) aircraft engine fueled with sustainable aviation fuel is a promising option for general aviation and unmanned aerial vehicle propulsion due to its high power-to-weight ratio, uniform torque output, and flexible valve ...
Zheng Xu +14 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source