Results 91 to 100 of about 965,816 (315)

Initial testing of a variable-stroke Stirling engine [PDF]

In support of the U.S. Department of Energy's Stirling Engine Highway Vehicle Systems Program, NASA Lewis Research Center is evaluating variable-stroke control for Stirling engines.
Thieme, L. G.
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Effect of exhaust nozzle configuration on aerodynamic and acoustic performance of an externally blown flap system with a quiet 6:1 bypass ratio engine [PDF]

A highly suppressed TF-34 engine was used to investigate engine and flap interaction noise associated with an externally blown flap STOL powered lift system. Noise, efficiency, and velocity decay characteristics of mixed and separate flow exhaust systems
Heidelberg, L. J., Jones, W. L., Samanich, N. E.   +2 more
core   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

An Adaptive Whole‐Body Control Approach for Dynamic Obstacle Avoidance of Mobile Manipulators for Human‐Centric Smart Manufacturing

IET Collaborative Intelligent Manufacturing
In human‐centric smart manufacturing (HCSM), the robot's dynamic obstacle avoidance function is crucial to ensuring human safety. Unlike the static obstacle avoidance of manipulators or mobile robots, the dynamic obstacle avoidance in mobile manipulators
Yong Tao, He Gao, Donghua Tan, Jiahao Wan, Baicun Wang, Chengxi Li, Pai Zheng   +6 more
doaj   +1 more source

A novel configuration for single-crystal superalloy hollow blade manufacturing based on shell/core integral mold

Journal of Materials Research and Technology
Shell/core integral mold fabricated by additive manufacturing possess high shell/core bonding strength, which is promising to improve the dimensional accuracy and integrity of single-crystal (SX) hollow blade while improving the manufacturing efficiency.
Binqiang Wang, Zhexu Li, Kun Bu, Zhongliang Lu, Jiawei Zhang, Sheng Mou, Shengjie Ren, Haoyu Zhao   +7 more
doaj   +1 more source

Tip gap size effects on thermal performance of cavity-winglet tips in transonic turbine cascade with endwall motion

Journal of the Global Power and Propulsion Society, 2017
The thermal performance of two cavity-winglet tips with endwall motion is investigated in a transonic high pressure turbine cascade, which operates at an engine representative exit Mach number of 1.2 and an exit Reynolds number of 1.7 × 106.
Fangpan Zhong, Chao Zhou
doaj   +1 more source

Computer simulation of engine systems [PDF]

The use of computerized simulations of the steady state and transient performance of jet engines throughout the flight regime is discussed. In addition, installation effects on thrust and specific fuel consumption is accounted for as well as engine ...
Fishbach, L. H.
core   +1 more source

Brownian Carnot engine [PDF]

, 2015
The Carnot cycle imposes a fundamental upper limit to the efficiency of a macroscopic motor operating between two thermal baths. However, this bound needs to be reinterpreted at microscopic scales, where molecular bio-motors and some artificial micro ...
A Bérut, D. Petrov, E Roldán, E Roldán, F Curzon, G Verley, G Verley, GE Crooks, GM Wang, H Ouerdane, I. A. Martínez, IA Martínez, IA Martínez, J Gieseler, J Gieseler, J Howard, J Millen, J Roßnagel, J. M. R. Parrondo, JV Koski, K Proesmans, K Sekimoto, K Sekimoto, K Sekimoto, L. Dinis, M Esposito, M Polettini, M Sarikaya, MVS Bonanca, P Mestres, R Feynman, R. A. Rica, S Carnot, S Toyabe, SM Douglas, TR Gingrich, U Seifert, V Blickle, É. Roldán   +38 more
core   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source