Results 71 to 80 of about 25,670,789 (354)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

The Effect of Break Edge Configuration on the Aerodynamics of Anti-Ice Jet Flow

EPJ Web of Conferences, 2015
One of the components of a turboprop gas turbine engine is the Front Bearing Structure (FBS) which leads air into the compressor. FBS directly encounters with ambient air, as a consequence ice accretion may occur on its static vanes.
Tatar V., Yildizay H., Aras H.
doaj   +1 more source

MULTIAGENT SYSTEMS ENGINEERING [PDF]

International Journal of Software Engineering and Knowledge Engineering, 2001
This paper describes the Multiagent Systems Engineering (MaSE) methodology. MaSE is a general purpose, methodology for developing heterogeneous multiagent systems. MaSE uses a number of graphically based models to describe system goals, behaviors, agent types, and agent communication interfaces.
Scott A. DeLoach, Mark F. Wood, Clint H. Sparkman   +2 more
openaire   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Reuse in Systems Engineering [PDF]

IEEE Systems Journal, 2010
Reuse in systems engineering is a frequent but poorly understood phenomenon. Nevertheless, it has a significant impact on system development and on estimating the appropriate amount of systems engineering effort with models like the Constructive Systems Engineering Cost Model (COSYSMO).
Gan Wang, Ricardo Valerdi, Julie Fortune
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Non-parametric models in the monitoring of engine performance and condition: Part 1: modelling of non-linear engine processes

, 1999
This paper proposes the use of radial basis function (RBF) networks in the modelling of non-linear engine processes. A pertinent application of such a model is the reconstruction of cylinder pressure based upon the instantaneous angular velocity of the ...
Jacob, P J, Gu, Fengshou, Ball, Andrew
core   +1 more source

Influence of Quenching Height and Air Distribution Ratio on Combustion Characteristics of RQL Combustor

Shanghai Jiaotong Daxue xuebao
Based on the principle of the rich-burn/quench/lean-burn (RQL) technology, a low emission combustion chamber for gas turbine was designed. The effects of different heights of quenching structure and distribution ratios of the air flow on the flow field ...
HUI Lei, LIU Aiguo, WU Xiaoqu, ZHANG Yunjie, ZENG Wen
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

On the engineering of systems of systems: Key challenges for the Requirements Engineering community [PDF]

2011 Workshop on Requirements Engineering for Systems, Services and Systems-of-Systems, 2011
Software intensive systems of the future will be ultra large-scale systems of systems. Systems of Systems Engineering focuses on the interoperation of many independent, self-contained constituent systems to achieve a global need. The scale and complexity of systems of systems possess unique challenges for the Requirements Engineering community. Current
openaire   +1 more source