Results 61 to 70 of about 965,816 (315)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
EnergiesExamining fuel droplet evaporation is crucial for enhancing fuel engine efficiency, conserving energy, and reducing emissions. This study utilizes experimental methods involving ultrasonic standing wave levitation and high-speed cameras to investigate ...
Bin Pang +8 more
doaj +1 more source
PROSPECTS OF DEVELOPMENT ELECTRONIC AUTOMATIC CONTROL SYSTEMS FOR GAS-TURBINE ENGINES
Авіаційно-космічна техніка та технологія, 2018 The analysis of the basic directions of electronic automatic control systems for aviation gas-turbine engines (FADEC) development is presented. This analysis is executed on the base of materials of the Scientific and Technical Congress of Aero-Engine ...
Геннадий Степанович Ранченко +1 more
doaj +1 more source
Space engine safety system [PDF]
A rocket engine safety system was designed to initiate control procedures to minimize damage to the engine or vehicle or test stand in the event of an engine failure. The features and the implementation issues associated with rocket engine safety systems
Maul, William A., Meyer, Claudia M.
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
NASA propulsion controls research [PDF]
Multivariable control theory is applied to the design of multiple input and output engine controls. Highly-accurate, real-time engine simulations are utilized for control development and checkout.
Teren, F.
core +1 more source
Development of EPA aircraft piston engine emission standards [PDF]
, 1976 Piston engine light aircraft are significant sources of carbon monoxide in the vicinity of high activity general aviation airports. Substantial reductions in carbon monoxide were achieved by fuel mixture leaning using improved fuel management systems ...
Houtman, W.
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source