Results 41 to 50 of about 9,909,879 (292)

Technological Change from Analog to Digital

open access: yesAnnals of Business Administrative Science, 2014
Brusoni, Prencipe, and Pavitt (2001) posited that the digitization of aircraft engine control systems in the early 1980s caused loose organizational coupling.
Yuichiro MUKAI
doaj   +1 more source

Reuse in Systems Engineering [PDF]

open access: yesIEEE Systems Journal, 2010
Reuse in systems engineering is a frequent but poorly understood phenomenon. Nevertheless, it has a significant impact on system development and on estimating the appropriate amount of systems engineering effort with models like the Constructive Systems Engineering Cost Model (COSYSMO).
Gan Wang, Ricardo Valerdi, Julie Fortune
openaire   +4 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

New perspectives on Web search engine research [PDF]

open access: yes, 2012
Purpose–The purpose of this chapter is to give an overview of the context of Web search and search engine-related research, as well as to introduce the reader to the sections and chapters of the book.
Lewandowski, Dirk
core  

Coded Control of a Sectional Electroelastic Engine for Nanomechatronics Systems

open access: yesApplied System Innovation, 2021
This work determines the coded control of a sectional electroelastic engine at the elastic–inertial load for nanomechatronics systems. The expressions of the mechanical and adjustment characteristics of a sectional electroelastic engine are obtained ...
Sergey M. Afonin
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Performance of Fuel Electronic Injection Engine Systems [PDF]

open access: yes, 2017
Electronic Fuel Injection systems are very important components in today’s automotive industry. Its use on modern engines allows manufactures to develop new engine designs while increasing engine efficiency and lowering fuel consumption and exhaust gas ...
Abonyi Sylvester, E   +2 more
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Control of High-Load Compressor Stator Corner Flow by Blade Slotting

open access: yesInternational Journal of Aerospace Engineering
Flow separation often occurs in the stator corner of a compressor, especially in a highly loaded compressor. Therefore, there are multiple methods for flow control, such as blade slotting, which uses the pressure difference between the pressure surface ...
Enbo Liu, Zhenggui Zhou, Huan Zheng
doaj   +1 more source

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