Results 51 to 60 of about 965,816 (315)

Reuse in Systems Engineering [PDF]

IEEE Systems Journal, 2010
Reuse in systems engineering is a frequent but poorly understood phenomenon. Nevertheless, it has a significant impact on system development and on estimating the appropriate amount of systems engineering effort with models like the Constructive Systems Engineering Cost Model (COSYSMO).
Gan Wang, Ricardo Valerdi, Julie Fortune
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Measurement-based Formulation of Quantum Heat Engine

, 2017
There exist two formulations for quantum heat engine that models an energy transfer between two microscopic systems. One is semi-classical scenario, and the other is full quantum scenario.
Hayashi, Masahito, Tajima, Hiroyasu
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Influence of Quenching Height and Air Distribution Ratio on Combustion Characteristics of RQL Combustor

Shanghai Jiaotong Daxue xuebao
Based on the principle of the rich-burn/quench/lean-burn (RQL) technology, a low emission combustion chamber for gas turbine was designed. The effects of different heights of quenching structure and distribution ratios of the air flow on the flow field ...
HUI Lei, LIU Aiguo, WU Xiaoqu, ZHANG Yunjie, ZENG Wen
doaj   +1 more source

On the engineering of systems of systems: Key challenges for the Requirements Engineering community [PDF]

2011 Workshop on Requirements Engineering for Systems, Services and Systems-of-Systems, 2011
Software intensive systems of the future will be ultra large-scale systems of systems. Systems of Systems Engineering focuses on the interoperation of many independent, self-contained constituent systems to achieve a global need. The scale and complexity of systems of systems possess unique challenges for the Requirements Engineering community. Current
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A comprehensive aerodynamic-thermal-mechanical design method for fast response turbocharger applied in aviation piston engines

Propulsion and Power Research
Limited by the poor transient response performance of turbochargers, the dynamic performance of aviation piston engines tends to deteriorate. In a bid to enhance the turbocharger's acceleration capabilities, this study scrutinizes various factors ...
Yu Zhou, Yue Song, Shuai Zhao, Xueyu Li, Longtao Shao, Huansong Yan, Zheng Xu, Shuiting Ding   +7 more
doaj   +1 more source

Effects of injection pressure and impingement distance on flat-wall impinging spray flame and its heat flux under diesel engine-like condition

Advances in Mechanical Engineering, 2019
Heat loss is one of the main causes of energy losses in modern direct injection diesel engines. This heat loss of the engine occurs during combustion, mainly due to the heat transfer between the impinging spray flame and the piston cavity wall.
Rizal Mahmud, Toru Kurisu, Keiya Nishida, Yoichi Ogata, Jun Kanzaki, Onur Akgol   +5 more
doaj   +1 more source