Results 41 to 50 of about 957,254 (314)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Quantum Synchronisation in Nanoscale Heat Engines

, 2019
Owing to the ubiquity of synchronization in the classical world, it is interesting to study its behavior in quantum systems. Though quantum synchronisation has been investigated in many systems, a clear connection to quantum technology applications is ...
Fazio, Rosario, Hajdušek, Michal, Jaseem, Noufal, Kwek, Leong-Chuan, Vedral, Vlatko, Vinjanampathy, Sai   +5 more
core   +1 more source

Environmental Impact Assessment, on the Operation of Conventional and More Electric Large Commercial Aircraft [PDF]

, 2013
Global aviation is growing exponentially and there is a great emphasis on trajectory optimization to reduce the overall environmental impact caused by aircraft. Many optimization techniques exist and are being studied for this purpose.
Lawson, Craig P., Sabatini, Roberto, Seresinhe, R.   +2 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Effectiveness of the Speed Reduction Strategy on Exhaust Emissions and Fuel Oil Consumption of a Marine Generator Engine for DC Grid Ships

Journal of Marine Science and Engineering, 2022
Recent developments in power electronics, energy storage systems, and renewable energy; increased market demands for more efficient and cleaner electric power to meet stricter environmental regulations; and development in gigawatt (GW)-class DC (direct ...
Van Chien Pham, Hanseok Kim, Jae-Hyuk Choi, Antony J. Nyongesa, Jongsu Kim, Hyeonmin Jeon, Won-Ju Lee   +6 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Control of High-Load Compressor Stator Corner Flow by Blade Slotting

International Journal of Aerospace Engineering
Flow separation often occurs in the stator corner of a compressor, especially in a highly loaded compressor. Therefore, there are multiple methods for flow control, such as blade slotting, which uses the pressure difference between the pressure surface ...
Enbo Liu, Zhenggui Zhou, Huan Zheng
doaj   +1 more source

The Effect of Break Edge Configuration on the Aerodynamics of Anti-Ice Jet Flow

EPJ Web of Conferences, 2015
One of the components of a turboprop gas turbine engine is the Front Bearing Structure (FBS) which leads air into the compressor. FBS directly encounters with ambient air, as a consequence ice accretion may occur on its static vanes.
Tatar V., Yildizay H., Aras H.
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source