Results 101 to 110 of about 14,992,249 (292)

Design and design centers in engineering education

Artificial Intelligence for Engineering Design, Analysis and Manufacturing, 1998
This paper is intended to be the opening salvo of the workshop, Computing Futures in Engineering Design (Dym, 1997). Thus, I want to take this privileged moment to ask you to think with me about the role of design in engineering. In particular, I want to reflect upon how design is articulated and how design is taught; about the role of design in ...
openaire   +3 more sources

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Rethinking Sketching: Integrating Hand Drawings, Digital Tools, and AI in Modern Design

Designs
The increasing digitization of design processes has profoundly transformed the role of sketching in industrial design, integrating it with advanced technologies such as artificial intelligence (AI).
Giampiero Donnici, Giulio Galiè, Leonardo Frizziero   +2 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Controlling the Material Width of Equation-Based Lattices for Large-Scale Additive Manufacturing

Journal of Manufacturing and Materials Processing
Additive manufacturing (AM) developments have been strongly driven by the ability of AM to improve the strength-to-weight ratios of structures, in contrast to traditional manufacturing methods, heavily supported by lattice structures.
Martha Baldwin, Joseph Bartolai, Joseph W. Fisher, Simon W. Miller   +3 more
doaj   +1 more source

A Future Vision For The Engineering Design Environment: A Future Sociotechnical Scenario

, 2003
This paper presents a future vision for the working practices of designers within a manufacturing organisation. By its very nature the engineering design environment is highly distributed in nature and is characterised by a large number of information ...
Richard Crowder, Mike Moss, Hall, W, Wendy Hall, Hall, Wendy, Chris Clegg, Clegg, Chris, Moss, M, Bracewell, RH, Waterson, Patrick, Hughes, G, Wallace, KM, Wallace, Ken, Knott, David, David Knott, Kerr, M, Hughes, Gareth, Ken Wallace, Patrick Waterson, Gareth Hughes, Knott, D, Crowder, R, Crowder, Richard, ,, Rob Bracewell, Kerr, Micky, Clegg, C, Waterson, P, Micky Kerr, Bracewell, Rob, Moss, Mike   +30 more
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

An Integrated BIM–NLP Framework for Design-Informed Automated Construction Schedule Generation

Designs
Artificial intelligence has attracted increasing attention in the construction industry; however, automated time scheduling remains limited in practical applications.
Mahmoud Donia, Emad Elbeltagi, Ahmed Elhakeem, Hossam Wefki   +3 more
doaj   +1 more source

A Two-Stage Model of Adaptable Product Platform for Engineering-to-Order Configuration Design

, 2015
Product platforms are used to enable mass-customization to serve a large number of different market segments. The products are configured-to-order, meaning they are compiled using a variety of pre-developed building blocks.
Jiao, Jianxin (Roger), Jiao, Jianxin (Roger),, Levandowski, Christoffer E, Levandowski, Christoffer E,, Johannesson, Hans L,, Johannesson, Hans L   +5 more
core   +1 more source