Results 81 to 90 of about 14,992,249 (292)

Design for Values in Engineering

, 2014
Values have probably always played a role in engineering design. However, in current practices and design methods, the attention for values in engineering design tends to be implicit and unsystematic. Establishing Design for Values in engineering would require overcoming this situation.
openaire   +4 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Potential for innovative massive building envelope systems – Scenario development towards integrated active systems

Journal of Facade Design and Engineering, 2015
In order to generate possible scenarios about future developments of massive constructions, this paper explains the developmental paths on the basis of individual materials of clay/brick as well as concrete/lightweight concrete/aerated concrete and sand ...
Ulrich Knaack
doaj  

A Multi-Strategy Improved Honey Badger Algorithm for Engineering Design Problems

Algorithms
A multi-strategy improved honey badger algorithm (MIHBA) is proposed to address the problem that the honey badger algorithm may fall into local optimum and premature convergence when dealing with complex optimization problems.
Tao Han, Tingting Li, Quanzeng Liu, Yourui Huang, Hongping Song   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Learning to Engineer: Integrating Robotics-Centred Project-Based Learning in Early Undergraduate Education

Education Sciences
Engineering programmes have been giving more weight to experiential learning, largely because many students still find it difficult to see how classroom theory connects to the work that engineers handle on the ground.
Pg Emeroylariffion Abas
doaj   +1 more source

Perception of Complexity in Engineering Design

Systems Engineering, 2021
This paper evaluates perception of complexity in a novel explanatory model that relates product performance and engineering effort. Complexity is an intermediate factor with two facets: it enables desired product performance but also requires effort to achieve.
openaire   +4 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The stress peak at the borehole of point-fitted IGU with undercut anchors

Journal of Facade Design and Engineering, 2014
Corresponding author: Mike Tibolt, ArcelorMittal Chair of Steel and Façade Engineering, University of Luxembourg. E-mail: mike.tibolt@uni.lu The highest transparency in glass facades is obtained with point fitted glass units.
Mike Tibolt, Christoph Odenbreit
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source