Results 61 to 70 of about 14,992,249 (292)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Innovative design tool for the optimization of blast-enhanced facade systems

Journal of Facade Design and Engineering, 2015
In current blast enhancement design strategies, to resist the effects of an accidental explosion, a facade system is commonly designed to behave in-elastically and undergo large deformations. The large deformation of the facade system leads to high blast
Marc Zobec, Guido Lori, Raymond Lumantarna, Tuan Ngo, Cuong Nguyen   +4 more
doaj  

Experimental Analysis and Design of 3D-Printed Polymer Elliptical Tubes in Compression

Applied Sciences
Local failure modes occurring in 3D-printed polymer elliptical section tubes in compression are investigated in the present study via a series of experiments, with the results compared to existing design proposals for slender steel analogues.
Finian McCann, Federico Rossi, Shahzada Danyal Sultan   +2 more
doaj   +1 more source

Engineering Design and Society [PDF]

SSRN Electronic Journal, 2017
As a discipline, engineering is rooted in mathematics and natural sciences; as a practice, it is social at its core. Social science is a more recent development than the society that it seeks to document and understand. Bringing social science into engineering design has its pros and cons.
openaire   +1 more source

Improved knowledge management through first-order logic in engineering design ontologies [PDF]

, 2010
This paper presents the use of first-order logic to improve upon currently employed engineering design knowledge management techniques. Specifically, this work uses description logic in unison with Horn logic, to not only guide the knowledge acquisition ...
Ian R. Grosse, Jack C. Wileden, Paul Witherell, Witherell, Paul, Witherell, P, Sundar Krishnamurty, Krishnamurty, S, Krishnamurty, Sundar, Grosse, Ian, Wileden, Jack, Wileden, JC, Grosse, IR   +11 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A completely transparent, adhesively bonded soda-lime glass block masonry system

Journal of Facade Design and Engineering, 2015
A pioneering, all transparent, self-supporting glass block facade is presented in this paper. Previously realized examples utilize embedded metal components in order to obtain the desired structural performance despite the fact that these elements ...
F. Oikonomopoulou, F. Veer, R. Nijsse, K. Baardolf   +3 more
doaj  

Towards Computer-Supported Functional Modelling in Engineering Design Education

Education Sciences
The growing need for solutions that can support the computer-based and distant assessment of functional models has resulted in ad hoc implementations of various diagramming tools.
Tomislav Martinec, Filip Valjak, Nikola Horvat, Nenad Bojčetić   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Requirements and Characteristics for the Development and Selection of Design Methods

Designs
While many design methods are developed, tested and reported in the literature, their utilization in industry practice remains low. Design methods are receiving substantial scholarly focus and are considered central to efficiently achieving reliable ...
Johannes Matschewsky, Sergio A. Brambila-Macias, Abhijna Neramballi, Tomohiko Sakao   +3 more
doaj   +1 more source