Results 51 to 60 of about 1,011,340 (268)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
A completely transparent, adhesively bonded soda-lime glass block masonry system
Journal of Facade Design and Engineering, 2015 A pioneering, all transparent, self-supporting glass block facade is presented in this paper. Previously realized examples utilize embedded metal components in order to obtain the desired structural performance despite the fact that these elements ...
F. Oikonomopoulou +3 more
doaj
Towards Computer-Supported Functional Modelling in Engineering Design Education
Education SciencesThe growing need for solutions that can support the computer-based and distant assessment of functional models has resulted in ad hoc implementations of various diagramming tools.
Tomislav Martinec +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Requirements and Characteristics for the Development and Selection of Design Methods
DesignsWhile many design methods are developed, tested and reported in the literature, their utilization in industry practice remains low. Design methods are receiving substantial scholarly focus and are considered central to efficiently achieving reliable ...
Johannes Matschewsky +3 more
doaj +1 more source
An Explicit Creep-Fatigue Model for Engineering Design Purposes
Metals, 2018 Background: Creep-fatigue phenomena are complex and difficult to model in ways that are useful from an engineering design perspective. Existing empirical-based models can be difficult to apply in practice, have poor accuracy, and lack economy.
Dan Liu, Dirk John Pons
doaj +1 more source
RE-DESIGNING THE LIBRARY FOR DESIGN ENGINEERING
Proceedings of the Canadian Engineering Education Association (CEEA), 2011 This paper relates our experience at the Engineering & Science Library at Queen’s University, melding Library resources into the design engineering curriculum in the Faculty of Applied Science. Effective library support of design engineering comprises people, curriculum, collections and assessment.
Murphy, Sharon, Saleh, Nasser
openaire +3 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source