Results 71 to 80 of about 4,649,067 (302)
Weight–strength optimization of wooden household chairs based on member section size
Maderas: Ciencia y Tecnología, 2022 Weight-strength optimization of wooden household chairs was performed based on the member section size in this study. Member section sizes of the Scotch pine (Pinus sylvestris) and Oriental beech (Fagus orientalis) chairs were optimized and resulting re-
Ersan Güray, Erkan Ceylan, Ali Kasal
doaj
A practical application for machine design education
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018 Machine design is perhaps the most important course for Mechanical Engineering students. There are many diverse approaches to the design education in universities worldwide.
Hüseyin R. BÖRKLÜ +3 more
doaj +1 more source
Issues Affecting Security Design Pattern Engineering [PDF]
, 2013 Security Design Patterns present the tried and tested design decisions made by security engineers within a well documented format. Patterns allow for complex security concepts, and mechanisms, to be expressed such that non domain experts can make use of ...
de Muijnck-Hughes, Jan, Duncan, Ishbel
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
The 24 hour challenge: creating a multidiscipline environment for design and entrepreneurship in engineering and design. Enhancing Employability through Enterprise Education [PDF]
, 2014 This Innovation and Creative Exchange (ICE) is an inter-school enterprise opportunity exclusively for second year Engineering and Design students at the University of Huddersfield.
Power, Jess
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
South African Journal of Industrial Engineering, 2016 This paper synthesises an overview of various models of the engineering design process with an overview of the most relevant theories within the field of creativity studies to conclude that (i) creativity plays a role throughout the engineering design ...
Oosthuizen, L., Vlok, P. J.
doaj +1 more source
OntoEng: A design method for ontology engineering in information systems [PDF]
, 2009 This paper addresses the design problem relating to ontology engineering in the discipline of information systems. Ontology engineering is a realm that covers issues related to ontology development and use throughout its life span.
Al-Debei, MM, Fitzgerald, G
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source