Results 71 to 80 of about 14,992,249 (292)

An Explicit Creep-Fatigue Model for Engineering Design Purposes

Metals, 2018
Background: Creep-fatigue phenomena are complex and difficult to model in ways that are useful from an engineering design perspective. Existing empirical-based models can be difficult to apply in practice, have poor accuracy, and lack economy.
Dan Liu, Dirk John Pons
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

RE-DESIGNING THE LIBRARY FOR DESIGN ENGINEERING

Proceedings of the Canadian Engineering Education Association (CEEA), 2011
This paper relates our experience at the Engineering & Science Library at Queen’s University, melding Library resources into the design engineering curriculum in the Faculty of Applied Science. Effective library support of design engineering comprises people, curriculum, collections and assessment.
Murphy, Sharon, Saleh, Nasser
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emotional design engineering for packaging of olive oil using machine learning techniques

Cogent Engineering
Consumer behaviour, and therefore purchase intentions, are affected by the visual elements of packaging. This is particularly important for products in the agri-food sector, especially for olive oil.
Ana de las Heras, Francisco Zamora-Polo, Antonio Ferramosca, Amalia Luque   +3 more
doaj   +1 more source

A framework for design engineering education in a global context [PDF]

, 2010
This paper presents a framework for teaching design engineering in a global context using innovative technologies to enable distributed teams to work together effectively across international and cultural boundaries.
Ion, W.J., Liefer, L., Eris, O., Hilary J. Grierson, Breslin, C., William J. Ion, Ade Mabogunje, Wodehouse, A.J., Andrew J. Wodehouse, Mabogunje, A., Grierson, H., Ozgur Eris, Caroline Breslin, Larry J. Leifer   +13 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Data-driven engineering design research: Opportunities using open data [PDF]

, 2017
Engineering Design research relies on quantitative and qualitative data to describe design-related phenomena and prescribe improvements for design practice.
Parraguez Ruiz, Pedro, Maier, Anja
core   +3 more sources

Enhanced Henry Gas Solubility Optimization for Solving Data and Engineering Design Problems

Eng
Many engineering design problems are formulated as constrained optimization tasks that are nonlinear and nonconvex, and often treated as black boxes. In such cases, metaheuristic algorithms are attractive because they can search complex design spaces ...
Jamal Zraqou, Ayman Alnsour, Riyad Alrousan, Hussam N. Fakhouri, Niveen Halalsheh   +4 more
doaj   +1 more source