Results 111 to 120 of about 1,008,712 (292)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Topological search and gradient descent boosted Runge–Kutta optimiser with application to engineering design and feature selection

CAAI Transactions on Intelligence Technology
The Runge–Kutta optimiser (RUN) algorithm, renowned for its powerful optimisation capabilities, faces challenges in dealing with increasing complexity in real‐world problems.
Jinge Shi, Yi Chen, Ali Asghar Heidari, Zhennao Cai, Huiling Chen, Guoxi Liang   +5 more
doaj   +1 more source

Design engineering

Abstract This chapter explains design engineering as an engineering methodology applied to human-computer interaction systems. It presents methods for clarifying a task and arriving at a conceptual design. It discusses verification and validation.
Kasper Hornbæk, Per Ola Kristensson, Antti Oulasvirta   +2 more
openaire   +1 more source

Application of Ecological Water Conservancy Engineering Design in Water Conservancy Construction

, 2023
Shu-Shan Li
openalex   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Sustainability - its incorporation into the mechanical engineering design process [PDF]

, 2014
Anthony Johnson
openalex  

The Effect Of A Teacher Professional Development Integrated Curriculum Workshop On Perceptions Of Design, Engineering, And Technology Experiences [PDF]

, 2020
Karen High, Pasha Antonenko, Rebecca Damron, Susan Stansberry, G. Donald Hudson, Jean Dockers, Alonzo Peterson   +6 more
openalex   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

JFDE Special Issue Glass

Journal of Facade Design and Engineering, 2014
Ulrich Knaack, Tillmann Klein
doaj   +1 more source