Results 51 to 60 of about 183,006 (319)

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

PECULIARITIES OF USING THE METHODOLOGY DISTANCE LEARNING OF THE SUBJECT «ENGINEERING AND COMPUTER GRAPHICS» FOR STUDENTS STUDYING BY CORRESPONDENCE

Інформаційні технології і засоби навчання, 2010
A great part of the distance course of the subject «Engineering and Computer Graphics» (ECG) placed in Internet looks as an electronic manual. But the distance training process has a complicated structure and combines not only studying theoretical ...
Olena V. Slobodianiuk
doaj  

A comparative study on teaching methods of engineering drawing course 1

آموزش مهندسی ایران, 2012
According to the modeling software and computer technology, teaching engineering graphics courses in Iranian universities must be improved similar to other top universities in the world which have changed since 2000.
Mehdi Mottaghipour
doaj   +1 more source

Let’s draw molecules: Students’ sequential drawing processes of resonance structures in organic chemistry

Frontiers in Education, 2022
Drawing is a fundamental skill in science, technology, engineering, and mathematics (STEM) disciplines to express one’s reasoning and externalize mental models in problem-solving.
Irina Braun, Axel Langner, Nicole Graulich   +2 more
doaj   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

An Automated Engineering Assistant: Learning Parsers for Technical Drawings [PDF]

arXiv, 2019
From a set of technical drawings and expert knowledge, we automatically learn a parser to interpret such a drawing. This enables automatic reasoning and learning on top of a large database of technical drawings. In this work, we develop a similarity based search algorithm to help engineers and designers find or complete designs more easily and flexibly.
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Segmentation method of U-net sheet metal engineering drawing based on CBAM attention mechanism [PDF]

arXiv, 2022
In the manufacturing process of heavy industrial equipment, the specific unit in the welding diagram is first manually redrawn and then the corresponding sheet metal parts are cut, which is inefficient. To this end, this paper proposes a U-net-based method for the segmentation and extraction of specific units in welding engineering drawings.
arxiv  

An enzyme‐linked immunosorbent assay (ELISA)‐based activity assay for AMP‐activated protein kinase (AMPK)

FEBS Open Bio, EarlyView.
Measuring AMP‐activated protein kinase (AMPK) activity in vitro is crucial for testing AMPK activators or inhibitors with therapeutic potential. Here, we report an enzyme‐linked immunosorbent assay (ELISA)‐based AMPK activity assay with simple steps and high sensitivity, which offers a simple, robust, and cost‐effective alternative to traditional ...
Trezze P. Nguyen, Shangze Lyu, Yang Liu
wiley   +1 more source