Results 71 to 80 of about 2,373,501 (286)
Retractable roofs in engineering education
Technical Transactions, 2020 This paper presents a proposal for updating and expanding the teaching of technical university students concerning the subject of roofs. Through the analysis of Polish textbooks and teaching studies, a lack of information on retractable roofs was ...
Pawlak-Jakubowska Anita +1 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Technical and vocational education in Malaysia: policy, leadership, and professional growth on Malaysia women [PDF]
, 2015 Technical and Vocational Education (TVE) is facing new challenges in an increasingly competitive global context. The continuing under representation of women in engineering fields at semi-skilled and high-skilled levels is receiving renewed attention ...
Lai, Chee Sern +3 more
core +1 more source
ENGINEERING EDUCATION: PRACTICE-ORIENTED APPROACH
Высшее образование в России, 2017 The paper substantiates the need to strengthen the practical orientation of engineering education in modern socio-economic conditions. The paper shows that introduction of context-related tasks during classroom hours correspond to the implementation of ...
N. N. Dvulichanskaya, V. B. Piasetsky
doaj
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Approaches to the teaching of design : an engineering subject centre guide [PDF]
, 2009 This booklet seeks to provide a resource for all those with an interest in design, and the education and training of engineering students to carry out the design process.
Mclaren, Andrew
core
The Application of Artificial Intelligence in Engineering Education: A Systematic Review
IEEE AccessArtificial Intelligence (AI) is increasingly impacting the environment, pedagogy, and management practices in engineering education. However, literature reviews that provide a systematic review and analysis of AI in engineering education remain limited ...
Cong Liu +2 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Engineering enterprise through intellectual property education - pedagogic approaches [PDF]
, 2005 Engineering faculties, despite shrinking resources, are delivering to new enterprise agendas that must take account of the fuzzying of disciplinary boundaries.
Childs, B. +3 more
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