Results 111 to 120 of about 819,536 (350)

Values in Water [PDF]

open access: yes, 2018
Inaugural speech spoken in acceptance of the chair ‘Ethics of water engineering’ at the Faculty of Technology, Policy and Management of Delft University of Technology on 16 November ...
Doorn, Neelke
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Rethinking sustainability in engineering education: a call for systemic change

open access: yesFrontiers in Education
The integration of engineering education with sustainability is a major requirement in overcoming global environmental, social, and economic challenges.
Omar K. Sabri
doaj   +1 more source

Alfred Marshall’s Puzzles. Between Economics as a Positive Science and Economic Chivalry [PDF]

open access: yes, 2015
Alfred Marshall’s approach to economics hides a paradox. On one hand, the ‘father’ of neoclassical economics strongly favoured conducting economics as a positive science.
Dzionek-Kozłowska, Joanna
core  

Strategies for teaching professional ethics to IT engineering degree students and evaluating the result [PDF]

open access: yes, 2017
This paper presents an experience in developing professional ethics by an approach that integrates knowledge, teaching methodologies and assessment coherently. It has been implemented for students in both the Software Engineering and Computer Engineering
Miñano Rubio, Rafael   +3 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Engineering ethics and the future [PDF]

open access: yes, 2016
Responding to the demands of the technology-driven global economy, engineers increase their technical competencies, improve cross-cultural communication skills, and become more innovative, entrepreneurial and flexible (Continental, 2006).
Fell, Elena Vladimirovna   +2 more
core   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

The Engineer as an Educator: Goods, Virtues, and Secondary Practices

open access: yesStudies in Logic, Grammar and Rhetoric
How should ethical standards be maintained within engineering and engineering education? The present paper addresses this question with relation to the dominant models of engineering ethics (EE) to show that their limits might be overcome by ...
Machura Piotr
doaj   +1 more source

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