Results 91 to 100 of about 840,567 (303)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Dilemmas and Solutions for Sustainability-Based Engineering Ethics: Lessons Learned from the Collapse of a Self-Built House in Changsha, Hunan, China

Buildings
With the rapid development of engineering construction in China, especially the emergence of large-scale engineering projects and self-built residential houses, ethical issues in engineering have become increasingly prominent.
Dina Tang, Minshui Huang
doaj   +1 more source

TOWARD SOFTWARE ENGINEERING PRINCIPLES BASED ON ISLAMIC ETHICAL VALUES

International Islamic University Malaysia Engineering Journal, 2010
Software is the core for Computer-based applications which became an essential part for critical control systems, health and human life guard systems, financial and banking systems, educational and other systems.
shihab A. Hameed
doaj   +1 more source

Reflections on Professional Engineering Ethics - a Personalistic Perspective [PDF]

, 2012
Tryb dostępu: http://mbace.eu/1. Purpose The article attempts to synthesize professional engineering ethics to find key characteristic features of a professional expert engineer and of a managing engineer, who do their duties on job contracts or as ...
Wajszczyk, Piotr
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The Engineer as an Educator: Goods, Virtues, and Secondary Practices

Studies in Logic, Grammar and Rhetoric
How should ethical standards be maintained within engineering and engineering education? The present paper addresses this question with relation to the dominant models of engineering ethics (EE) to show that their limits might be overcome by ...
Machura Piotr
doaj   +1 more source

Alfred Marshall’s Puzzles. Between Economics as a Positive Science and Economic Chivalry [PDF]

, 2015
Alfred Marshall’s approach to economics hides a paradox. On one hand, the ‘father’ of neoclassical economics strongly favoured conducting economics as a positive science.
Dzionek-Kozłowska, Joanna
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Introducing Preservice STEM Teachers to Computer Science: A Narrative of Theoretically Oriented Design [PDF]

, 2018
This paper narrates the process of designing a curricular unit that serves to introduce preservice science, technology, engineering, and mathematics (STEM) teachers to computer science (CS) education.
Harron, Jason
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source