Results 51 to 60 of about 2,890,467 (353)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Using Reflexive Principlism to Investigate Longitudinal Changes in Engineering Students’ Perceptions of Ethics

Studies in Engineering Education
Background: Studies of changes in engineering students’ perceptions of ethics and social responsibility over time have often resulted in mixed results or shown only small longitudinal shifts.
Stephanie A. Claussen, Lazlo Stepback, Brent K. Jesiek, Carla B. Zoltowski, Shiloh James Howland   +4 more
doaj   +1 more source

The risks of hydraulic fracturing and the responsibilities of engineers

Elementa: Science of the Anthropocene, 2017
One third of U.S. natural gas is extracted by injecting fluid at high pressure into shale formations, a process associated with a number of possible hazards and risks that have become the subject of intense public controversy.
Robert Kirkman, Chloé F. Arson, Lauren Stewart, Rebecca Harris, Amanda Francis   +4 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Profession-oriented textbook of English for engineering students as a tool for developing the axiological component of prospective specialist’s professional culture

Вестник Тамбовского университета. Серия: Гуманитарные науки
Importance. The important issue of developing profession-oriented foreign language textbooks for students of non-linguistic fields of study, in which the acquisition of foreign language communicative skills could be accompanied by the formation of ...
M. G. Evdokimova, E. S. Davidenko
doaj   +1 more source

Identifying and Ranking the Components of Engineering Ethics with a Multi-Criteria Decision-Making Approach

آموزش مهندسی ایران, 2020
Engineering ethics deals with moral issues and decisions confronting individuals and organizations engaged in engineering, and it is, therefore, the ability and the responsibility of all engineers to evaluate their decisions based on the general well ...
mahdi safaei , Ardalan Feili , omid jabari , seyed ahmad Jenabali Jahromi   +3 more
doaj   +1 more source

The Ethics of Engineering

, 2019
If you were to picture an engineer's work day, the image that comes to mind will probably be of a person developing a new product in a lab or carrying out complicated technical calculations. You would probably not picture that person reflecting on the values embedded in a product's design or whether the technology created might cause prejudice to users
openaire   +3 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

The Design Education of the New Era Urgent Needs to Cultivate Engineering Ethics Consciousness

MATEC Web of Conferences, 2018
By expounding the inseparable relationship between design and engineering ethics, and comparing the current situation of the development of engineering ethics education at home and abroad, we find that there is a big gap between China's design ...
Wenming Liu
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source