Results 51 to 60 of about 819,536 (350)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Research on Evolutionary Game of Engineering Community Members from the Perspective of Engineering Ethics [PDF]

open access: yesE3S Web of Conferences, 2020
Engineering ethics is a system of ethical principles applied to engineering, which plays the role of value guidance and criterion evaluation in engineering construction activities.
Zhu Ziming, Song Yuanzhen, Qin Menglin
doaj   +1 more source

Ethics and Engineering Education [PDF]

open access: yes, 2008
A presentation made at a Workshop on Philosophy and Engineering, Technical University of Delft, October 2007. A much shorter version of this paper has been submitted for consideration in the EUROPEAN JOURNAL OF ENGINEERING EDUCATION 2008 Société ...
Bucciarelli, Louis
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Engineering Ethics is Global Concerning

open access: yesآموزش مهندسی ایران, 2010
Engineering ethics and morals in engineering are rather new subjects in engineering education and activities. Because of engineering activities which create and change the world, as well as to sustain the world life, deals with a new definition of ...
Jalal Hejazi
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Technological Engineering Education and Ethics of Conduct [PDF]

open access: yesEngineering and Technology Journal, 2019
The presence of ethical conduct within university institutions promote positive attitude among employees these institutions also provide them with a reference to which they revert to determine what is the proper conduct. The commitment to compliance with
Ibtisam Hasan   +2 more
doaj   +1 more source

IDENTIFYING THE RELATIONSHIP BETWEEN TECHNICAL ENGINEERING GRADUATES’ COMPETENCIES AND ENTREPRENEURIAL SPIRIT WITH THE MEDIATION OF ENGINEERING PROFESSIONAL ETHICS

open access: yesآموزش مهندسی ایران, 2023
The present study was conducted with the aim of testing the causal relationship between the competencies of engineering science graduates and entrepreneurship with the mediating role of engineering professional ethics. The research method was applied and
M. Ezati, Z. Al-Sadat Mostafavi
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

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