Results 51 to 60 of about 822,555 (308)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Using Reflexive Principlism to Investigate Longitudinal Changes in Engineering Students’ Perceptions of Ethics

Studies in Engineering Education
Background: Studies of changes in engineering students’ perceptions of ethics and social responsibility over time have often resulted in mixed results or shown only small longitudinal shifts.
Stephanie A. Claussen, Lazlo Stepback, Brent K. Jesiek, Carla B. Zoltowski, Shiloh James Howland   +4 more
doaj   +1 more source

The risks of hydraulic fracturing and the responsibilities of engineers

Elementa: Science of the Anthropocene, 2017
One third of U.S. natural gas is extracted by injecting fluid at high pressure into shale formations, a process associated with a number of possible hazards and risks that have become the subject of intense public controversy.
Robert Kirkman, Chloé F. Arson, Lauren Stewart, Rebecca Harris, Amanda Francis   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Investigating the emphasis on the educational ethics at the engineering universities of Iran and comparing it with top engineering universities of the world

آموزش مهندسی ایران, 2020
The purpose of this research is to investigate the emphasis on the educational ethics at the engineering universities of Iran and comparing with top engineering universities of the world.
Hossein Abdullahi , Saide Taghizade   +1 more
doaj   +1 more source

Teaching ethics to engineering undergraduates - lessons learned and a guide for lecturers: perspective from an English University [PDF]

, 2012
The issue of ethics within engineering profession has been gaining more and more importance due to globalisation, increasing awareness of sustainability and the fast changing business culture within engineering organisations.
Hasan, Reaz
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Profession-oriented textbook of English for engineering students as a tool for developing the axiological component of prospective specialist’s professional culture

Вестник Тамбовского университета. Серия: Гуманитарные науки
Importance. The important issue of developing profession-oriented foreign language textbooks for students of non-linguistic fields of study, in which the acquisition of foreign language communicative skills could be accompanied by the formation of ...
M. G. Evdokimova, E. S. Davidenko
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

TEACHING OF ETHICS IN ENGINEERING UNDERGRADUATE PROGRAMS: TECNOLÓGICO NACIONAL DE MÉXICO’S CASE

Ra Ximhai, 2019
Considering the huge boom that the integration of ethical notions in college education has had in universities around the world, this work is a research about this process in Mexico’s National Tech (TecNM).
Jorge Alberto Olayo-Valles, Estrella Evelyn Armenta-Verdugo, Zenia Isabel Castro-Borunda, María Azucena Caro-Dueñas   +3 more
doaj   +1 more source