Results 61 to 70 of about 840,567 (303)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Etyka budowania wizerunku w kodeksach etyki inżynierskiej [PDF]

, 2014
The article discusses problems of image development in selected professional engineering communities, as expressed in their ethical codes. Specific codified norms are presented and their likely effects discussed on two levels: personal and social.
Wajszczyk, Piotr
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Code of professional ethics of engineering in Iran

آموزش مهندسی ایران, 2015
Professional ethics set of regulations and rules which define ethical practice for that profession specifically. Engineering ethics in general is the application of code of ethics and professional standards.
Mehran Rahmani, Javad Majrouhi
doaj   +1 more source

Ethical and Social Aspects of Self-Driving Cars

, 2018
As an envisaged future of transportation, self-driving cars are being discussed from various perspectives, including social, economical, engineering, computer science, design, and ethics.
Dodig-Crnkovic, Gordana, Holstein, Tobias, Pelliccione, Patrizio   +2 more
core   +1 more source

Engineering the Climate: The Ethics of Solar Radiation Management [PDF]

, 2017
This important edited collection addresses ethical issues associated with solar radiation management (SRM), a category of climate engineering techniques that would increase the planet’s reflectivity in order to offset some of the impacts of anthropogenic
Svoboda, Toby
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Deliberating stratospheric aerosols for climate geoengineering and the SPICE project [PDF]

, 2013
Increasing concerns about the narrowing window for averting dangerous climate change have prompted calls for research into geoengineering, alongside dialogue with the public regarding this as a possible response.
A Corner, A Corner, A Irwin, A Rip, A Stirling, AP Nielsen, B Wynne, BA Turner, C Hamilton, C Marris, D Bhattachary, D Fiorino, DH Guston, HD Matthews, HJ Buck, J Brown, J Chilvers, J Chilvers, J Lezaun, JS Dryzek, K Bickerstaff, K Parkhill, M Callon, M Philbrick, MD Cobb, NE Vaughan, NF Pidgeon, NF Pidgeon, NF Pidgeon, NF Pidgeon, NF Pidgeon, O Renn, O Renn, P Harremoës, P Macnaghten, P Macnaghten, R Owen, RV Burri, S Jasanoff, S Rayner, SM Gardiner, T Dietz, T Rogers-Hayden   +42 more
core   +2 more sources