Results 121 to 130 of about 4,743,133 (351)

Protein Engineering for Nicotinamide Coenzyme Specificity in Oxidoreductases: Attempts and Challenges

Frontiers in Microbiology, 2018
Oxidoreductases are ubiquitous enzymes that catalyze an extensive range of chemical reactions with great specificity, efficiency, and selectivity. Most oxidoreductases are nicotinamide cofactor-dependent enzymes with a strong preference for NADP or NAD ...
Andrea M. Chánique, Loreto P. Parra, Loreto P. Parra   +2 more
doaj   +1 more source

Designing by Geometry. Rankine's Theorems of Transformation of Structures. [PDF]

, 2010
William John Macquorn Rankine (1820-1872) was one of the main figures in establishing engineering science in the second half of the 19th. Century. His Manual of Applied Mechanics (1858) gathers most of his contributions to strength of materials and ...
Huerta Fernández, Santiago
core   +1 more source

The Refined Topological Vertex

, 2009
We define a refined topological vertex which depends in addition on a parameter, which physically corresponds to extending the self-dual graviphoton field strength to a more general configuration.
, A. Iqbal, A. Iqbal, A. Iqbal, A. Iqbal, A. Okounkov, Amer Iqbal, C. Faber, Can Kozçaz, Cumrun Vafa, H. Awata, H. Nakajima, H. Nakajima, H. Nakajima, I.G. Macdonald, J. Bryan, M. Haiman, N. Nekrasov, N.A. Nekrasov, R. Gopakumar, S. Gukov, S. Katz, T.J. Hollowood, Y. Tachikawa   +23 more
core   +2 more sources

A generic platform for the immobilisation of engineered biocatalysts

Tetrahedron, 2019
Abstract The application of biocatalysis in the pharmaceutical industry is rapidly growing as a result of increased access to enzymes that meet the demands of industrial processes. This expansion of activity has led to a corresponding increase in the demand for immobilised enzymes.
Thompson, Matthew P., Derrington, Sasha R., Heath, Rachel S., Porter, Joanne L., Mangas-Sanchez, Juan, Devine, Paul N., Truppo, Matthew D., Turner, Nicholas J.   +7 more
openaire   +3 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Preliminary report on the general geology and engineering geology of Noonan quadrangle, North Dakota [PDF]

, 1947
Roland C. Townsend
openalex   +1 more source

Analysis of adhesives in general engineering [PDF]

, 2009
Předkládaná bakalářská práce se zabývá analýzou lepidel ve všeobecném strojírenství a je zaměřena na rozdělení lepidel dle vytvrzení a vhodnosti použití. Dále je zde charakterizováno příznivé a nepříznivé mechanické namáhání lepených spojů. Na konci této
Trhoň, Vojtěch
core  

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

SIGNS LANGUAGE IN GRAPHICAL COMMUNICATION MECHANICAL DRAWING: THE BASIC LANGUAGE IN GRAPHICAL COMMUNICATION

Journal of Industrial Design and Engineering Graphics, 2010
The paper presents general notions about graphical language used in engineering, the international standards used for representing objects and also the most important software applications used in Computer Aided Design for the development of products in ...
BADEA Florina, PETRESCU Ligia
doaj  

IN THE MATTER OF AN APPLICATION TO THE COMPTROLLER-GENERAL BY THE LOEWY ENGINEERING COY. LD. UNDER SEC. 56 OF THE ACT [PDF]

, 1952

openalex   +1 more source