Results 81 to 90 of about 4,743,133 (351)

Generative Software Engineering

The rapid development of deep learning techniques, improved computational power, and the availability of vast training data have led to significant advancements in pre-trained models and large language models (LLMs). Pre-trained models based on architectures such as BERT and Transformer, as well as LLMs like ChatGPT, have demonstrated remarkable ...
Huang, Yuan, Chen, Yinan, Chen, Xiangping, Chen, Junqi, Peng, Rui, Tang, Zhicao, Huang, Jinbo, Xu, Furen, Zheng, Zibin   +8 more
openaire   +2 more sources

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Mathematical modeling technique

AIP Advances, 2019
In this paper, a general modeling principle is introduced that was found useful for modeling complex physical systems for engineering applications.
R. T. Longo
doaj   +1 more source

Experiences with mechatronics education at the University of Twente [PDF]

, 2003
This paper describes the experiences with a number of variants of mechatronic programmes offered by the University of Twente since 1989. Mechatronics education took place in a two-year mechatronic designer programme, in specialisations in Electrical and ...
Amerongen, Job van
core   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Inverse design of cooperative electromagnetic interactions

, 2013
The cooperative electromagnetic interactions between discrete resonators have been widely used to modify the optical properties of metamaterials. Here we propose a general evolutionary approach for engineering these interactions in arbitrary networks of ...
Ben-Abdallah, Philippe, Besbes, Mondher, Hugonin, Jean-Paul, Langlais, Mathieu   +3 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Exploring Students’ Experiences with Mindfulness Meditations in a First-Year General Engineering Course

Education Sciences
With growing mental health concerns among college students, they need to effectively develop skills to alleviate stress amidst the demands of university life.
Larkin Martini, Mark Vincent Huerta, Jazmin Jurkiewicz, Brian Chan, Diana Bairaktarova   +4 more
doaj   +1 more source

Multidisplinary Engineering, Project, and Production Management [PDF]

Journal of Engineering, Project, and Production Management, 2012
Journal of Engineering, Project, and Production Management (EPPM-Journal) reflect the journal’s multidisciplinary approach to management research and can be categorized as belonging to three general topics: Project Management, Engineering and Project ...
Chien-Ho Ko
doaj  

Early Childhood Science and Engineering: Engaging Platforms for Fostering Domain-General Learning Skills

Education Sciences, 2018
Early childhood science and engineering education offer a prime context to foster approaches-to-learning (ATL) and executive functioning (EF) by eliciting children’s natural curiosity about the world, providing a unique opportunity to engage ...
Andres S. Bustamante, Daryl B. Greenfield, Irena Nayfeld   +2 more
doaj   +1 more source