Results 61 to 70 of about 1,465,434 (267)
Energy efficiency in civil engineering: analyzing world experience
MATEC Web of Conferences, 2018 There are consistent trends in the development of energy-saving technologies in civil engineering in almost all countries of the world. The article considers the main approaches to ensuring energy efficiency in in civil engineering, analyzes the ...
Bezdenezhnukh Tatiana +2 more
doaj +1 more source
Photogrammetry Laser Scanning and Reverse Engineering Conrad’s Jewel [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information SciencesLaser scanning, photogrammetry, and other technical tools are staples for cultural heritage documentation and reverse engineering projects. However, manufacturers and even researchers often conflate the data capture process with reverse engineering ...
A. Weigert +3 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
GEO: Generative Engine Optimization
Proceedings of the 30th ACM SIGKDD Conference on Knowledge Discovery and Data MiningThe advent of large language models (LLMs) has ushered in a new paradigm of search engines that use generative models to gather and summarize information to answer user queries. This emerging technology, which we formalize under the unified framework of generative engines (GEs), can generate accurate and personalized responses, rapidly replacing ...
Pranjal Aggarwal +5 more
openaire +2 more sources
Generic Comparison of Protein Inference Engines
Molecular & Cellular Proteomics, 2012 Protein identifications, instead of peptide-spectrum matches, constitute the biologically relevant result of shotgun proteomics studies. How to appropriately infer and report protein identifications has triggered a still ongoing debate. This debate has so far suffered from the lack of appropriate performance measures that allow us to objectively assess
Claassen M. +4 more
openaire +4 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A Comparison of Beginning and Advanced Engineering Students’ Description of Information Skills
Evidence Based Library and Information Practice, 2015 Objective – The purpose of this research was to examine how beginning and advanced level engineering students report use of information when completing an engineering design process.
Kerrie Anna Douglas +4 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source