Results 71 to 80 of about 5,028,054 (300)

Analysis of the scientific production of the Spanish Software Engineering Community [PDF]

open access: yes, 2015
Our group has been working on a report for the Spanish Society of Software Engineering and Software Development Technologies (SISTEDES) to provide a general overview of the Spanish scientific production and its contributions worldwide in the field of ...
Burgueño, Loli   +2 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Annotated bibliography of Software Engineering Laboratory literature [PDF]

open access: yes
An annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory is given. More than 100 publications are summarized.
Morusiewicz, Linda, Valett, Jon D.
core   +4 more sources

Generative Software Engineering

open access: yes
The rapid development of deep learning techniques, improved computational power, and the availability of vast training data have led to significant advancements in pre-trained models and large language models (LLMs). Pre-trained models based on architectures such as BERT and Transformer, as well as LLMs like ChatGPT, have demonstrated remarkable ...
Huang, Yuan   +8 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Functional planning and occupational safety of milk production in cold loose housing barns [PDF]

open access: yes, 2004
The study charted the most serious occupational hazards of cold loose housing barns. Furthermore, the study gave a good general picture of cold loose housing barns (CLHB) in dairy production.
Karttunen, Janne
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

A Comparison of Beginning and Advanced Engineering Students’ Description of Information Skills

open access: yesEvidence Based Library and Information Practice, 2015
Objective – The purpose of this research was to examine how beginning and advanced level engineering students report use of information when completing an engineering design process.
Kerrie Anna Douglas   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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