Results 71 to 80 of about 3,645,822 (281)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Four considerations on interdisciplinary learning at the boundaries of human and engineering sciences

Frontiers in Education, 2022
Philipp Beckerle, Philipp Beckerle, Chenxu Hao, Daniel F. B. Haeufle, Daniel F. B. Haeufle, Nele Russwinkel   +5 more
doaj   +1 more source

Qualitative software engineering research -- reflections and guidelines

, 2020
Researchers are increasingly recognizing the importance of human aspects in software development and since qualitative methods are used to, in-depth, explore human behavior, we believe that studies using such techniques will become more common ...
Feldt, Robert, Graziotin, Daniel, Gren, Lucas, Lenberg, Per, Tengberg, Lars Göran Wallgren, Tidefors, Inga   +5 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

A model decomposition method for the real-time non-line-of-sight imaging

iScience
Summary: Real-time non-line-of-sight (NLOS) imaging faces a fundamental trade-off between acquisition efficiency and reconstruction quality. Although transient methods achieve high visual fidelity, they depend on extensive data collection. Regularization-
Peng Yang, Zewei Wang, Yinghui Guo, Xiaoying Li, Mingbo Pu, Hengshuo Guo, Mingfeng Xu, Fei Zhang, Yuanmao Wang, Xiangang Luo   +9 more
doaj   +1 more source

Engineering tissues with a perfusable vessel-like network using endothelialized alginate hydrogel fiber and spheroid-enclosing microcapsules

Heliyon, 2016
Development of the technique for constructing an internal perfusable vascular network is a challenging issue in fabrication of dense three-dimensional tissues in vitro. Here, we report a method for realizing it. We assembled small tissue (about 200 μm in
Yang Liu, Shinji Sakai, Masahito Taya
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Proceedings of the Salford Postgraduate Annual Research Conference (SPARC) 2011 [PDF]

, 2012
These proceedings bring together a selection of papers from the 2011 Salford Postgraduate Annual Research Conference(SPARC). It includes papers from PhD students in the arts and social sciences, business, computing, science and engineering, education ...
Al Azawi, W, Al Ghazali, FAM, Al Jameel, H, Al Rawahi, M, Aljunaidy, MM, Berlin, J, Darlington, J, Demetriou, K, Demir, ST, Doran, C, Egbu, JU, Elagili, GY, Elferjani, M, Elmagri, MI, Elmsallati, NA, Griffiths, L, Hamlyn, CP, Hardman, M, Khashkhush, AS, Kiddy, PA, Lord, JD, Masrilayanti, M, Mohamed, MII, Morrison, SA, Mwenesongole, E, Opoku, A, Ozmen, ES, Rigby, MJ, ur Rehman, S, Yates, MT, Yusufu, AS   +30 more
core  

The Consequences of Polyandry for Sibship Structures, Distributions of Relationships and Relatedness, and Potential for Inbreeding in a Wild Population [PDF]

, 2017
We thank the Tsawout and Tseycum First Nations for access to Mandarte Island, Pirmin Nietlisbach, Lukas Keller, Greta Bocedi, Brad Duthie, and Matthew Wolak for helpful discussions, and the European Research Council, National Sciences and Engineering ...
Arcese, Peter, Germain, Ryan R., Reid, Jane M.   +2 more
core   +2 more sources