Results 201 to 210 of about 4,724,242 (392)
, 2013 This essay describes Jack\u27s experience dealing with World Cup fever in Bath, England, during the 2010 World Cup. It\u27s Jack\u27s outsider\u27s perspective on the impact of world cup competition while he taught in the Advanced Studies in England ...
Ryan, Jack
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Advanced Synthesis &Catalysis, EarlyView.We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg +5 more
wiley +1 more source
TES: A modular systems approach to expert system development for real-time space applications [PDF]
A major goal of the Space Station era is to reduce reliance on support from ground based experts. The development of software programs using expert systems technology is one means of reaching this goal without requiring crew members to become intimately ...
Cacace, Ralph, England, Brenda
core +1 more source
Advanced Therapeutics, EarlyView.This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack +13 more
wiley +1 more source
The New England rental market [PDF]
New England’s rental prices are high but relatively affordable to most residents.Housing - New England ; Housing - Prices - New England ; Rental housing - New ...
Alicia Sasser
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Advanced Science, EarlyView.In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan +20 more
wiley +1 more source
New England states are facing their worst fiscal crises in at least a decade. General revenues, especially those from the personal income tax, fell sharply in every New England state except New Hampshire in FY2002.
Amanda Lydon +1 more
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Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Advanced Science, EarlyView.Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source
Advanced Science, EarlyView.CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian +12 more
wiley +1 more source
How does mortality compare between different countries/regions of birth for the population of England and Wales, 2007 to 2021? A descriptive, observational study. [PDF]
J R Soc MedHiam L, Minton J, Burns R, Aldridge RW.
europepmc +1 more source