Results 41 to 50 of about 770,797 (339)

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Students’ Perceptions and Attitudes toward World Englishes Paradigm

Journal of English Education and Teaching, 2023
The study aims to describe the pre-service English teachers’ perceptions and attitudes toward World Englishes (WE) Paradigm from Kachru's theory within the Indonesian context.
Sri Imelwaty, Yulistia Rahmi Putri, Sesmiyanti   +2 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Pivot Through English: Reliably Answering Multilingual Questions without Document Retrieval [PDF]

arXiv, 2020
Existing methods for open-retrieval question answering in lower resource languages (LRLs) lag significantly behind English. They not only suffer from the shortcomings of non-English document retrieval, but are reliant on language-specific supervision for either the task or translation.
arxiv  

Evaluation of the dose reduction effect of crystalline lens exposure in cone‐beam computed tomography with bismuth eye shield for image‐guided radiation therapy: An anthropomorphic phantom study

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract This study aimed to evaluate the dose‐exposure reduction effect of a crystalline lens with a bismuth eye shield using cone‐beam computed tomography (CBCT) for head image‐guided radiation therapy. The ocular surface dose of the head phantom (THRA‐1) is defined as a crystalline lens exposure dose and is measured using a radiophotoluminescence ...
Tatsuya Yoshida, Koji Sasaki, Yoshiyuki Kawasaki, Tomoki Hayakawa, Toshiyuki Kawadai, Takako Shibasaki   +5 more
wiley   +1 more source

Teaching English Using Digital Flashcards to Improve Grammar Skills of Junior High School Students [PDF]

E3S Web of Conferences
Although digital flashcards are popular among English teachers, initiatives to actually measure the differences before and after using digital flashcards for teaching were relatively scarce.
Rejeki Murtiningsih Sri, Nur Khasanah Auliya, Puspitasari Evi   +2 more
doaj   +1 more source

Development of a generic focal spot measurement method suitable for bore‐type linacs

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose In linear accelerators, deviations in the x‐ray focal spot position significantly affect the accuracy of radiation therapy. However, as the focal spot position in bore‐type linac systems such as the Radixact system, cannot be assessed using conventional methods, a new evaluation method is required.
Hidetoshi Shimizu, Kazuharu Nishitani, Tomoki Kitagawa, Koji Sasaki, Takahiro Aoyama, Takeshi Kodaira   +5 more
wiley   +1 more source

Music Interventions in Hyperacute and Acute Stroke Patients: A Randomized Controlled Pilot Feasibility Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Music interventions have been shown to have beneficial effects on hemodynamic parameters, pain, and anxiety in various medical settings. However, music interventions in the setting of acute stroke have not been studied. The objective of this trial was to perform a pilot feasibility study of music interventions in the setting of acute
Jeffrey J. Fletcher, Allison Edberg, Ronald Grifka, Joan Westendorp, Augusto Elias, Jacquie Knott, Elizabeth Martin, Fazeel Siddiqui   +7 more
wiley   +1 more source

Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Postoperative delirium, a common neurocognitive complication after surgery and anesthesia, requires early detection for potential intervention. Herein, we constructed a multidimensional postoperative delirium risk‐prediction model incorporating multiple demographic parameters and blood biomarkers to enhance prediction accuracy ...
Hengjun Wan, Huaju Tian, Cheng Wu, Yue Zhao, Daiying Zhang, Yujie Zheng, Yuan Li, Xiaoxia Duan   +7 more
wiley   +1 more source