Results 51 to 60 of about 74,737 (213)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Assessing English Language Education Students’ Attitudes in Hybrid Learning Instructional Environments [PDF]

E3S Web of Conferences
This study investigates the perspectives of English Language Education Department (ELED) students at a private Islamic institution in Yogyakarta regarding hybrid learning environments post-COVID-19 pandemic.
Suryanto Suryanto, Purwanti Eko, Limbong Effendi, Sitorus Alwinsyah, Shinjee Bolormaa, Alsolami Turki   +5 more
doaj   +1 more source

Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel, Charlotte Hennessey, Hannah Lee, Pia Parekh, Sheng‐Han Kuo, Ami Kumar   +5 more
wiley   +1 more source

Investigating the role of mindful, meaningful, and joyful learning in promoting deep learning in AI-based language learning

Australian Journal of Applied Linguistics
This study aimed to investigate whether Mindful Learning (MiL), Meaningful Learning (MeL), and Joyful Learning (JL) are predictors of Deep Learning (DL) in AI-based language learning.
Made Hery Santosa, I Putu Indra Kusuma, Luh Gd Rahayu Budiarta   +2 more
doaj   +1 more source

Teaching English Using Digital Flashcards to Improve Grammar Skills of Junior High School Students [PDF]

E3S Web of Conferences
Although digital flashcards are popular among English teachers, initiatives to actually measure the differences before and after using digital flashcards for teaching were relatively scarce.
Rejeki Murtiningsih Sri, Nur Khasanah Auliya, Puspitasari Evi   +2 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

The use of interactional metadiscourse markers by Saudi EFL male and female college students: the case of a gender-sensitive topic

Humanities & Social Sciences Communications
A few studies have explored the use of interactional metadiscourse markers in argumentative writing by male and female college students. More importantly, none explored the topic of metadiscourse resources with respect to gender-sensitive topics.
Ghuzayyil Mohammed Al-Otaibi, Abeer Abdulhadi Hussain   +1 more
doaj   +1 more source