Results 51 to 60 of about 10,087,447 (327)

Fixation probabilities for any configuration of two strategies on regular graphs

, 2016
Population structure and spatial heterogeneity are integral components of evolutionary dynamics, in general, and of evolution of cooperation, in particular. Structure can promote the emergence of cooperation in some populations and suppress it in others.
Chen, Yu-Ting, McAvoy, Alex, Nowak, Martin A.   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The effect of geographical proximity on scientific cooperation among Chinese cities from 1990 to 2010. [PDF]

PLoS ONE, 2014
The relations between geographical proximity and spatial distance constitute a popular topic of concern. Thus, how geographical proximity affects scientific cooperation, and whether geographically proximate scientific cooperation activities in fact ...
Haitao Ma, Chuanglin Fang, Bo Pang, Guangdong Li   +3 more
doaj   +1 more source

Anglo-French defence cooperation in the age of austerity [PDF]

, 2013
This paper seeks to assess, from a predominantly UK perspective, the potential benefits of enhanced Anglo-French defence cooperation, not only to the two countries concerned but also to Western Europe and the USA.
Antill, Peter D., Ito, Pete, Robinson, Steve   +2 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Disorder enhances binding cooperativity [PDF]

Science, 2014
Biotechnology Some natural proteins, such as hemoglobin, bind their ligands in a cooperative manner, whereby the binding of the first ligand alters the structure of the protein, favoring binding of subsequent ligands. Taking inspiration from this mechanism, Simon et al.
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Direct reciprocity in spatial populations enhances R-reciprocity as well as ST-reciprocity. [PDF]

PLoS ONE, 2013
As is well-known, spatial reciprocity plays an important role in facilitating the emergence of cooperative traits, and the effect of direct reciprocity is also obvious for explaining the cooperation dynamics.
Kohei Miyaji, Jun Tanimoto, Zhen Wang, Aya Hagishima, Naoki Ikegaya   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators

Frontiers in Nutrition, 2019
Unmethylated cytosine–guanine dinucleotide (CpG) motifs are potent stimulators of the host immune response. Cellular recognition of CpG motifs occurs via Toll-like receptor 9 (TLR9), which normally activates immune responses to pathogen-associated ...
Shireen Nigar, Takeshi Shimosato
doaj   +1 more source