Results 71 to 80 of about 10,087,447 (327)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Toward a collaborative model of pandemic preparedness and response: Taiwan's changing approach to pandemics

Journal of Microbiology, Immunology and Infection, 2017
Background: Over time, as newly emerging infectious diseases have become increasingly common and more easily spread, it has become clear that traditional response mechanisms have proven inadequate to the task of prevention and control.
Jonathan Schwartz, Muh-Yong Yen
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Antisocial pool rewarding does not deter public cooperation

, 2015
Rewarding cooperation is in many ways expected behaviour from social players. However, strategies that promote antisocial behaviour are also surprisingly common, not just in human societies, but also among eusocial insects and bacteria.
Perc, Matjaz, Szolnoki, Attila
core   +2 more sources

Optimal interdependence between networks for the evolution of cooperation [PDF]

, 2013
Recent research has identified interactions between networks as crucial for the outcome of evolutionary games taking place on them. While the consensus is that interdependence does promote cooperation by means of organizational complexity and enhanced ...
A Halu, A Szolnoki, A Szolnoki, A Szolnoki, A Szolnoki, BJ Kim, C Gracia-Lázaro, C Gracia-Lázaro, C Hauert, CM Schneider, CP Roca, D Zhou, F Fu, F Fu, F Pinheiro, FC Santos, FC Santos, FC Santos, FC Santos, FC Santos, G Abramson, G Li, G Szabó, G Szabó, GI Simko, GJ Baxter, H Ebel, HW Lau, IG Portillo, J Gao, J Gómez-Gardeñes, J Gómez-Gardeñes, J Gómez-Gardeñes, J Gómez-Gardeñes, J Peña, J Poncela, J Poncela, J Poncela, J Tanimoto, J Tanimoto, JM Pacheco, KH Schlag, LE Blume, M Brede, M Brede, M Perc, M Perc, M Tomassini, M Tomassini, MA Nowak, MA Nowak, MG Zimmermann, MN Kuperman, N Masuda, N Masuda, P Csermely, R Dickman, R Parshani, R-H Li, S Assenza, S Gómez, S Havlin, S Lee, S-W Son, SV Buldyrev, TP Peixoto, X Huang, Y Wang, Z Rong, Z Wang, Z Wang, Z Wang, Z Wang   +72 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Adaptace českého právního řádu na zřízení Úřadu evropského veřejného žalobce

Acta Universitatis Carolinae. Iuridica, 2019
Council Regulation (EU) 2017/1939 of 12 October 2017 implementing enhanced cooperation on the establishment of the European Public Prosecutor’s Office (“the EPPO”) was published in the Official Journal of the European Union on 31 October 2017.
Jiří Pavlík
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Enhanced Cooperation in Corporate Taxation [PDF]

, 2011
In this thesis I study the harmful competition between national governments to attract multinational companies into their country, by designing a competitive corporate tax system.
Vrijburg, H. (Hendrik)
core   +2 more sources