Results 51 to 60 of about 512,744 (291)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Sensitivity Enhanced Photoacoustic Imaging Using a High-Frequency PZT Transducer with an Integrated Front-End Amplifier

Sensors, 2020
Photoacoustic (PA) imaging is a hybrid imaging technique that can provide both structural and functional information of biological tissues. Due to limited permissible laser energy deposited on tissues, highly sensitive PA imaging is required.
Chen Yang, Xiaohua Jian, Xinle Zhu, Jiabing Lv, Yang Jiao, Zhile Han, Antonios Stylogiannis, Vasilis Ntziachristos, George Sergiadis, Yaoyao Cui   +9 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Comparative analysis of choroidal thickness in third trimester pregnant women

International Journal of Retina and Vitreous, 2018
Background The impact of pregnancy on the choroid is still under investigation. The aim of this study is to compare choroidal thickness measurements of healthy pregnant women in the third trimester and healthy non-pregnant women using spectral-domain ...
Camila Zanella Benfica, Teresinha Zanella, Lucas Brandolt Farias, Maria Lúcia Rocha Oppermann, Luis Henrique Santos Canani, Daniel Lavinsky   +5 more
doaj   +1 more source

Multidimensional en-face OCT imaging of the retina. [PDF]

, 2009
Fast T-scanning (transverse scanning, en-face) was used to build B-scan or C-scan optical coherence tomography (OCT) images of the retina. Several unique signature patterns of en-face (coronal) are reviewed in conjunction with associated confocal images ...
Adrian G. Podoleanu, Cucu, de Boer, George M. Dobre, Gh, Gh, Gh, Gh, Gh, Gh, Gh, Gh, Hitzenberger, Hong, Huber, Jiao, John Rogers, Justin Pedro, Leitgeb, Lim, Mark Hathaway, Masters, Merino, Patricia Garcia, Philippe Laissue, Pircher, Pircher, Pircher, Pircher, Richard B. Rosen, Rosa, Tuohy, Van Velthoven, Wojtkowski, Yasuno   +34 more
core   +1 more source

Recovering Depth Map from Enhanced Image Gradients

Procedia Computer Science, 2015
AbstractThis paper presents a new and efficient approach for recovering surface height from its image gradients. In order to compensate noise effect in image intensities, Gaussian filter is used to smooth the intensity values. Image gradient is calculated from the smoothen image by taking the central difference of intensity values.
Bala, Anu, Kumar, Sanjeev, Bhargava, Rama   +2 more
openaire   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Depth Imaging Enhancement Using Reverse Time Migration

IOP Conference Series: Earth and Environmental Science, 2017
Imaging the subsurface with complex structures and steeply dipping salt boundaries is a challenging task in seismic exploration. Between two main categories of seismic migration, wavefield-continuation methods have been more successful than ray-based ones.
S.Y. Moussavi Alashloo, D.P. Ghosh, Y. Bashir, W.I. Wan Yusoff   +3 more
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Optimizing visualization in enhanced depth imaging OCT in healthy subjects and patients with retinal pigment epithelial detachment

Clinical Ophthalmology, 2012
Lukas Reznicek, Efstathios Vounotrypidis, Florian Seidensticker, Karsten Kortuem, Anselm Kampik, Aljoscha S Neubauer, Armin WolfDepartment of Ophthalmology, Ludwig Maximilians University Muenchen, Munich, GermanyBackground: This study’s ...
Kampik A, Kortuem K, Seidensticker F, Vounotrypidis E, Reznicek L, Neubauer AS, Wolf A   +6 more
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