Results 61 to 70 of about 512,744 (291)

Optical Coherence Tomography in Inflammatory and Neoplastic Lesions Deforming the Choroidal Profile

Diagnostics, 2023
The choroid is the main part of the uvea, the vascular layer of the eye that lies between the retina and the sclera. The high vascular component of the choroid makes this structure susceptible to inflammation in multisystemic diseases, as well as the ...
Elena Bolletta, Luca De Simone, Marco Pellegrini, Chiara Preziosa, Valentina Mastrofilippo, Chantal Adani, Pietro Gentile, Fabrizio Gozzi, Luca Cimino   +8 more
doaj   +1 more source

Two-Dimensional Helioseismic Power, Phase, and Coherence Spectra of {\it Solar Dynamics Observatory} Photospheric and Chromospheric Observables

, 2012
While the {\it Helioseismic and Magnetic Imager} (HMI) onboard the {\it Solar Dynamics Observatory} (SDO) provides Doppler velocity [$V$], continuum intensity [$I_C$], and line-depth [$Ld$] observations, each of which is sensitive to the five-minute ...
A. Fossum, A. Jiménez, A.A. Norton, B. Fleck, C. Barban, Charles S. Baldner, D.C. Braun, Deborah A. Haber, F. Hill, F.-L. Deubner, F.-L. Deubner, G. Severino, H. Schunker, J.M. Krijger, K. Muglach, K. Nagashima, Kiran Jain, P.F. Moretti, P.G. Judge, P.H. Scherrer, R. Howe, R. Howe, R. Howe, R. Jain, Rachel Howe, Richard S. Bogart, T. Sekii, T.M. Brown, W. Finsterle, Y. Elsworth   +29 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparison of enhanced depth imaging and high-penetration optical coherence tomography for imaging deep optic nerve head and parapapillary structures

Clinical Ophthalmology, 2013
Atsuya Miki, Yasushi Ikuno, Yukari Jo, Kohji NishidaDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, JapanPurpose: To evaluate and compare the abilities of enhanced depth imaging (EDI) and high-penetration optical ...
Miki A, Ikuno Y, Jo Y, Nishida K
doaj  

Evaluation of Choroidal Thickness in Normal Eyes Using Enhanced Depth Optical Coherence Tomography

Delhi Journal of Ophthalmology, 2017
Purpose: To evaluate the choroidal thickness in normal Indian population and to determine its correlation with age and refractive error Design: Cross sectional study conducted at a tertiary eye hospital in North India.
Harish, Shalini Singh, Manisha Agarwal, Rahul Mayor, Ramesh Venkatesh, Lokesh Chauhan   +5 more
doaj   +1 more source

Effect of Scattering Efficiency in the Tip Enhanced Raman Spectroscopic Imaging of Nanostructures in the Sub Diffraction Limit

, 2017
The experimental limitations in the signal enhancement and spatial resolution in spectroscopic imaging have been always a challenging task in the application of near-field spectroscopy for nanostructured materials in the sub-diffraction limit.
Chini, Tapas Kumar, Dhara, Sandip, Maity, Achyut, Patsha, Avinash, Sivadasan, A. K.   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation of the lamina cribrosa in patients with multiple sclerosis using enhanced depth imaging optical coherence tomography

Medicine Science, 2018
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Optic neuritis (ON) is common clinical manifestation of MS. Spectral domain optical coherence tomography (SD-OCT) has been used as a useful tool to quantify the neuronal ...
Serkan Akkaya, Bekir Kucuk, Ender Sirakaya, Ersin Kasim Ulusoy   +3 more
doaj   +1 more source

Focusing and Compression of Ultrashort Pulses through Scattering Media [PDF]

, 2011
Light scattering in inhomogeneous media induces wavefront distortions which pose an inherent limitation in many optical applications. Examples range from microscopy and nanosurgery to astronomy.
A Assion, A Derode, AM Weiner, BA Wilt, BJ Pearson, BK Andrasfalvy, C-L Hsieh, D Oron, D Oron, D Yelin, E Small, E Tal, Eran Small, F Lemoult, G Lerosey, H Rabitz, H Szmacinski, IM Vellekoop, IM Vellekoop, IM Vellekoop, IM Vellekoop, IM Vellekoop, J Aulbach, JC Diels, JM Dela Cruz, JW Goodman, M Aeschlimann, M Cui, M Fink, M Oheim, M Rueckel, MA Webster, MI Stockman, MJ Booth, NC Bruce, Ori Katz, P Sebbah, PM Johnson, RK Tyson, S Popoff, SM Popoff, T Čižmár, W Denk, Y Jiang, Yaron Bromberg, Yaron Silberberg, Z Yaqoob   +46 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source