Holistic bioengineering: rewiring central metabolism for enhanced bioproduction [PDF]
Biochemical Journal, 2017 What does it take to convert a living organism into a truly productive biofactory? Apart from optimizing biosynthesis pathways as standalone units, a successful bioengineering approach must bend the endogenous metabolic network of the host, and especially its central metabolism, to support the bioproduction process.
Aslan, Selçuk +2 more
openaire +4 more sources
New Insights on the Diurnal Mechanism of Calcification in the Stony Coral, Stylophora pistillata
Frontiers in Marine Science, 2022 Scleractinian corals are evolutionary-successful calcifying marine organisms, which utilize an endo-symbiotic relationship with photosynthetic dinoflagellate algae that supply energy products to their coral hosts.
Maayan Neder +6 more
doaj +1 more source
Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy [PDF]
, 2017 Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease mechanism and the finding that glial lipid metabolism is critical for axon function, independent of ...
Asadollahi, Ebrahim +17 more
core +3 more sources
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. [PDF]
, 2017 Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Cao, Hui +15 more
core +1 more source
E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells [PDF]
, 2018 RATIONALE: The majority of current cardiovascular cell therapy trials use bone marrow progenitor cells (BM PCs) and achieve only modest efficacy; the limited potential of these cells to differentiate into endothelial-lineage cells is one of the major ...
Boriboun, Chan +17 more
core +1 more source
Brassinosteroid regulates secondary metabolism in tomato towards enhanced tolerance to phenanthrene
Biologia Plantarum, 2013 We investigated the role of 24-epibrassinolide (EBR) in the amelioration of phenanthrene (PHE) stress in tomato (Solanum lycopersicum L.). Exposure to PHE (300 μM) significantly decreased shoot and root length (19 and 16 %, respectively), fresh mass (35 ...
G. J. Ahammed +5 more
doaj +1 more source
Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse. [PDF]
PLoS ONE, 2010 Although skeletal muscle metabolism is a well-studied physiological process, little is known about how it is regulated at the transcriptional level. The myogenic transcription factor myogenin is required for skeletal muscle development during embryonic ...
Jesse M Flynn +3 more
doaj +1 more source
Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization [PDF]
, 2016 Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals.
Bao, Yong P. +10 more
core +1 more source
Unpacking and understanding the impact of proprotein convertase subtilisin/kexin type 9 inhibitors on apolipoprotein B metabolism [PDF]
, 2017 No abstract ...
Packard, Chris J.
core +1 more source
Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts [PDF]
GeroScience, 2018 Inhibition of mTOR signaling using rapamycin has been shown to increase lifespan and healthspan in multiple model organisms; however, the precise mechanisms for the beneficial effects of rapamycin remain uncertain. We have previously reported that rapamycin delays senescence in human cells and that enhanced mitochondrial biogenesis and protection from ...
Timothy Nacarelli +4 more
openaire +2 more sources