Results 61 to 70 of about 3,646,500 (310)

Comprehensive analysis of the effects of foliar application of the synthetic strigolactone analog GR24 during the growth period on postharvest quality and metabolic indicators of pak choi

Food Chemistry: X
Strigolactones (SLs) regulate plant growth and metabolism, but their concentration-dependent effects on leafy vegetable quality remain unclear. We investigated how the synthetic SL analog GR24 affects physiological and metabolic processes in pak choi ...
Yufeng Ma, Qitong Cai, Cheng Wang, Yang Liu, Youlin Chang, Jing Zhang, Jianming Xie   +6 more
doaj   +1 more source

Tilting Plant Metabolism for Improved Metabolite Biosynthesis and Enhanced Human Benefit

Molecules, 2015
The immense chemical diversity of plant-derived secondary metabolites coupled with their vast array of biological functions has seen this group of compounds attract considerable research interest across a range of research disciplines.
Bhekumthetho Ncube, Johannes Van Staden
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination

Oncogenesis
Otto Warburg described tumour cells as displaying enhanced aerobic glycolysis whilst maintaining defective oxidative phosphorylation (OXPHOS) for energy production almost 100 years ago [1, 2].
Henna Myllymäki, Lisa Kelly, Abigail M. Elliot, Roderick N. Carter, Jeanette Astorga Johansson, Kai Yee Chang, Justyna Cholewa-Waclaw, Nicholas M. Morton, Yi Feng   +8 more
doaj   +1 more source

Root and Leaf-Specific Metabolic Responses of Ryegrass to Arbuscular Mycorrhizal Fungi Under Cadmium Stress

Journal of Fungi
Cadmium (Cd) drastically inhibits plant growth and metabolism, whereas arbuscular mycorrhizal (AM) fungi can enhance plant Cd tolerance through metabolic regulation.
Dapeng Jin, Lingyu Xin, Panpan Tu, Huiping Song, Yan Zou, Zhiwei Bian, Zhengjun Feng   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Assays to enhance metabolic phenotyping in the kidney

American Journal of Physiology-Renal Physiology
We show significant metabolic differences between both primary and immortalized cells, and among primary cells with different durations in cell culture. In addition, 3H-palmitate oxidation in tissue ex vivo is described as a method novel to the kidney for assessing the complete oxidation of long-chain fatty acids.
Safaa Hammoud, Justin Kern, Sandip Mukherjee, Andrew J. Lutkewitte, Prabhleen Singh, Kate Newberry, Brian N. Finck, Leslie S. Gewin   +7 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Methylene Blue as a Cerebral Metabolic and Hemodynamic Enhancer

PLoS ONE, 2012
By restoring mitochondrial function, methylene blue (MB) is an effective neuroprotectant in many neurological disorders (e.g., Parkinson's and Alzheimer's diseases). MB has also been proposed as a brain metabolic enhancer because of its action on mitochondrial cytochrome c oxidase.
Ai-Ling Lin, Ethan Poteet, Fang Du, Roy C Gourav, Ran Liu, Yi Wen, Andrew Bresnen, Shiliang Huang, Peter T Fox, Shao-Hua Yang, Timothy Q Duong   +10 more
openaire   +4 more sources