Results 51 to 60 of about 771,121 (268)

MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma

iScience, 2019
Summary: In pediatric neuroblastoma, MYCN-amplification correlates to poor clinical outcome and new treatment options are needed for these patients.
Ganna Oliynyk, María Victoria Ruiz-Pérez, Lourdes Sainero-Alcolado, Johanna Dzieran, Hanna Zirath, Héctor Gallart-Ayala, Craig E. Wheelock, Henrik J. Johansson, Roland Nilsson, Janne Lehtiö, Marie Arsenian-Henriksson   +10 more
doaj   +1 more source

Methylene Blue as a Cerebral Metabolic and Hemodynamic Enhancer

PLoS ONE, 2012
By restoring mitochondrial function, methylene blue (MB) is an effective neuroprotectant in many neurological disorders (e.g., Parkinson's and Alzheimer's diseases). MB has also been proposed as a brain metabolic enhancer because of its action on mitochondrial cytochrome c oxidase.
Ai-Ling Lin, Ethan Poteet, Fang Du, Roy C Gourav, Ran Liu, Yi Wen, Andrew Bresnen, Shiliang Huang, Peter T Fox, Shao-Hua Yang, Timothy Q Duong   +10 more
openaire   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Physiological, transcriptomic and metabolomic analyses reveal the mechanism of CuO and silicon nanoparticles involved in Polygonatum kingianum response to root rot

Chemical and Biological Technologies in Agriculture
Background Copper oxide nanoparticles (CuNPs) and silicon nanoparticles (SiNPs) play a crucial role in enhancing plant growth and development under stress conditions, making them valuable tools in sustainable agriculture. However, the mechanisms by which
Xi Xu, Jinpeng Wan, Guizhou Liu, Chengkai Lu, Xinyu Mao, Jinglin Wu, Hanying Liu, Yong Ding, Peng Xu   +8 more
doaj   +1 more source

Reducing Dietary Protein Content by Increasing Carbohydrates Is More Beneficial to the Growth, Antioxidative Capacity, Ion Transport, and Ammonia Excretion of Nile Tilapia (Oreochromis niloticus) under Long-Term Alkalinity Stress

Aquaculture Nutrition, 2023
Alkalinity stress is the main stress experienced by aquatic animals in saline–alkali water, which hinders the aquaculture development and the utilization of water resources.
Wei Liu, Chang Xu, Zhao Li, Liqiao Chen, Xiaodan Wang, Erchao Li   +5 more
doaj   +1 more source

Enhanced phosphocholine metabolism is essential for terminal erythropoiesis [PDF]

Blood, 2018
Key PointsPHOSPHO1 regulates phosphocholine metabolism, ATP production, and amino acid supply during erythropoiesis.
Huang, Nai-Jia, Lin, Ying-Cing, Lin, Chung-Yueh, Pishesha, Novalia, Lewis, Caroline A, Freinkman, Elizaveta, Farquharson, Colin; id_orcid 0000-0002-4970-4039, Millán, José Luis, Lodish, Harvey   +8 more
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Short Term Effect of Caffeine on Purine, Pyrimidine and Pyridine Metabolism in Rice () Seedlings

Natural Product Communications, 2015
As part of our studies on the physiological and ecological function of caffeine, we investigated the effect of exogenously supplied caffeine on purine, pyrimidine and pyridine metabolism in rice seedlings.
Wei-Wei Deng, Riko Katahira, Hiroshi Ashihara   +2 more
doaj   +1 more source

Transcriptome and metabolome analyses of two contrasting sesame genotypes reveal the crucial biological pathways involved in rapid adaptive response to salt stress

BMC Plant Biology, 2019
Background Soil salinity is one of the major serious factors that affect agricultural productivity of almost all crops worldwide, including the important oilseed crop sesame.
Yujuan Zhang, Donghua Li, Rong Zhou, Xiao Wang, Komivi Dossa, Linhai Wang, Yanxin Zhang, Jingyin Yu, Huihui Gong, Xiurong Zhang, Jun You   +10 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source