Results 71 to 80 of about 3,646,500 (310)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Enhanced phosphocholine metabolism is essential for terminal erythropoiesis [PDF]

Blood, 2018
Key PointsPHOSPHO1 regulates phosphocholine metabolism, ATP production, and amino acid supply during erythropoiesis.
Huang, Nai-Jia, Lin, Ying-Cing, Lin, Chung-Yueh, Pishesha, Novalia, Lewis, Caroline A, Freinkman, Elizaveta, Farquharson, Colin; id_orcid 0000-0002-4970-4039, Millán, José Luis, Lodish, Harvey   +8 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Enhanced Campus Life Executive Summary [PDF]

, 2013
The Enhanced Campus Life Working Group was formed by President Armstrong who identified an opportunity to create a culture for 24/7 campus life that meets the academic and social needs of the students, whether living on or off campus.
Enhanced Campus Life Working Group,
core  

The Carbohydrate Metabolism of Lactiplantibacillus plantarum

, 2021
Lactiplantibacillus plantarum has a strong carbohydrate utilization ability. This characteristic plays an important role in its gastrointestinal tract colonization and probiotic effects. L.
Yankun Zheng, Meihong Wang, Yanhua Cui, Xiaojun Qu, Kai Miao   +4 more
core   +1 more source

MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma

iScience, 2019
Summary: In pediatric neuroblastoma, MYCN-amplification correlates to poor clinical outcome and new treatment options are needed for these patients.
Ganna Oliynyk, María Victoria Ruiz-Pérez, Lourdes Sainero-Alcolado, Johanna Dzieran, Hanna Zirath, Héctor Gallart-Ayala, Craig E. Wheelock, Henrik J. Johansson, Roland Nilsson, Janne Lehtiö, Marie Arsenian-Henriksson   +10 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Succinate is an inflammation-induced immunoregulatory metabolite in macrophages

, 2020
Immunometabolism revealed the crucial role of cellular metabolism in controlling immune cell phenotype and functions. Macrophages, key immune cells that support progression of numerous inflammatory diseases, have been well described as undergoing vast ...
van Weeghel, Michel, Kyra E. de Goede, Harber, Karl J., Helga E. de Vries, de Winther, Menno P.J., Verberk, Sanne G. S., de Goede, Kyra E., van den Bossche, Jan, Menno P. J. de Winther, de Vries, Helga E., Karl J. Harber, Elisa Meinster, Sanne G. S. Verberk, Meinster, Elisa, Jan Van den Bossche, de Winther, Menno P. J., Verberk, Sanne G.S., Michel van Weeghel   +17 more
core   +1 more source

Physiological, transcriptomic and metabolomic analyses reveal the mechanism of CuO and silicon nanoparticles involved in Polygonatum kingianum response to root rot

Chemical and Biological Technologies in Agriculture
Background Copper oxide nanoparticles (CuNPs) and silicon nanoparticles (SiNPs) play a crucial role in enhancing plant growth and development under stress conditions, making them valuable tools in sustainable agriculture. However, the mechanisms by which
Xi Xu, Jinpeng Wan, Guizhou Liu, Chengkai Lu, Xinyu Mao, Jinglin Wu, Hanying Liu, Yong Ding, Peng Xu   +8 more
doaj   +1 more source

Short Term Effect of Caffeine on Purine, Pyrimidine and Pyridine Metabolism in Rice () Seedlings

Natural Product Communications, 2015
As part of our studies on the physiological and ecological function of caffeine, we investigated the effect of exogenously supplied caffeine on purine, pyrimidine and pyridine metabolism in rice seedlings.
Wei-Wei Deng, Riko Katahira, Hiroshi Ashihara   +2 more
doaj   +1 more source