Results 101 to 110 of about 668,045 (318)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Enhancement of Drought Tolerance in Cucumber Plants by Natural Carbon Materials
Plants, 2019 Stress induced by climate change is a widespread and global phenomenon. Unexpected drought stress has a substantial effect on the growth and productivity of valuable crops.
Tae Yoon Kim +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
New methods and applications in solid-state NMR spectroscopy of quadrupolar nuclei
, 2014 The authors acknowledge the EPSRC for the award of a studentship to S.S. Accepted Oct 8th 2014Solid-state nuclear magnetic resonance (NMR) spectroscopy has long been established as offering unique atomic-scale and element-specific insight into the ...
Ashbrook, Sharon E, Sneddon, Scott
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
BuildingsThe use of recycled coarse aggregates (RCA) in concrete production offers significant environmental and economic benefits. However, the high water absorption and low mechanical strength of RCA, caused by residual mortar and internal cracks, severely ...
Jian Wang +7 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Research on the Contrast Enhancement Algorithm for X-ray Images of BiFeO3 Material Experiment
Applied SciencesHigh-Temperature Materials Science Experiment Cabinet on the Chinese Space Station is mainly used to carry out experimental research related to high-temperature materials science in microgravity.
Xinze Li +3 more
doaj +1 more source
Performance Enhancement of Solar Stills with Novel Materials: A Concise Review [PDF]
Journal of Heat and Mass Transfer ResearchAccording to the severe global warming and increasing demand for freshwater worldwide, different sustainable solutions for supplying water have been considered.
Ahmed Alhamzawi
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source