Results 251 to 260 of about 519,199 (308)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

[Retracted] miR‑218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D. [PDF]

Oncol Rep
Cao Q, Dong P, Wang Y, Zhang J, Shi X, Wang Y.   +5 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation. [PDF]

Proc Natl Acad Sci U S A
Niu Z, Liu C, Fan Y, Gu L.
europepmc   +1 more source

Discovering the complete enhancer map of human herpesviruses using a natural language processing model. [PDF]

Nat Commun
Roy Chowdhury N, Ghosal D, Gurevich V, Shamay M.   +3 more
europepmc   +1 more source

Non-Coding Regulatory Variants in Autoimmune Disease: Biological Mechanisms, Immune Context, and Integrative Multi-Omics Interpretation. [PDF]

Biology (Basel)
Ali Agha ASA, Al-Zaki NA, Alshammari SAN, Odeh L, Obekh R, Sameer N, M Askari H, Hakooz N, Al-Adham I, Collier PJ.   +9 more
europepmc   +1 more source

CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer's disease. [PDF]

Nat Neurosci
Green NFO, Sutton GJ, Pérez-Burillo J, Wang J, Bagot S, Danon HG, Walsh K, Gokool A, Miles SA, Yang G, Herring CA, Liang Y, Pfundstein G, Sytnyk V, Alinejad-Rokny H, Lister R, Rosenbluh J, Gagnon-Bartsch JA, Voineagu I.   +18 more
europepmc   +1 more source

Silencer variants are key drivers of gene up-regulation in Alzheimer's disease. [PDF]

Sci Adv
Huang D, Ovcharenko I.
europepmc   +1 more source