Results 291 to 300 of about 9,209,436 (353)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions. [PDF]

Nat Commun
Lee H, Gkotinakou IM, McGrath CG, Krishnan B, Animesh S, Salinas I, Morris R, Sade-Feldman M, Haas W, Lawrence MS, Sanidas I.   +10 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

IL-10-STAT3-Dependent Transcriptional Regulation in Microglia: Alzheimer's Disease and Neuroinflammation. [PDF]

Biomedicines
Kim ME, Lee JS.
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The castration-resistant prostate cancer-associated SNP rs11067228 facilitates neuroendocrine differentiation through an enhancer-mediated chromatin interaction with SRRM4. [PDF]

Int J Biol Sci
Jiang Y, Zhao Z, Li P, Su G, Qian Y, Zhao Y, Wang B, Bai Y, Zhang L, Zhao Z, Shi J, Lu W.   +11 more
europepmc   +1 more source

The Histone-Lysine N-Methyltransferase (KMT2) Family in Health and Disease. [PDF]

MedComm (2020)
Wang Q, Bo Z, Zhang Y, Chen Y, Wang Z, Tong S, Xu A, Zhang J, Liu Y.   +8 more
europepmc   +1 more source

Identification of small molecules that enhance aminoglycoside-mediated suppression of <i>CFTR</i> and <i>NF1</i> nonsense mutations. [PDF]

Mol Ther Oncol
Sammons J, Chen J, Thrasher K, Fu L, Du M, Wen H, Bostwick JR, Vinson P, Moukha-Chafiq O, Augelli-Szafran C, Keeling KM, Wallis D, Kesterson RA, Rowe SM, Bedwell DM.   +14 more
europepmc   +1 more source

Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features. [PDF]

Nat Commun
Araujo Tavares RC, Dhir S, He X, Monahan J, Taipale M, Golder P, Ciau-Uitz A, Gosal W, Tannahill D, Balasubramanian S.   +9 more
europepmc   +1 more source

Multilayer Timing of Cardiac Circadian Regulation Informs Prevention and Treatment of Cardiovascular Disease. [PDF]

Vasc Health Risk Manag
Zhu L, Qian B, Zhang X, Hu LL.
europepmc   +1 more source