Results 71 to 80 of about 8,887,574 (403)
A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development [PDF]
, 2004 During C. elegans vulval development, the anchor cell (AC) in the somatic gonad expresses lin-3, activating the EGF receptor signaling pathway in vulval precursor cells (VPCs) and thereby inducing and patterning VPCs.
Hwang, Byung Joon, Sternberg, Paul W.
core +1 more source
Journal of Applied Philosophy, 2008 abstract Opponents of biomedical enhancement often claim that, even if such enhancement would benefit the enhanced, it would harm others. But this objection looks unpersuasive when the enhancement in question is a moral enhancement — an enhancement that will expectably leave the enhanced person with morally better motives than she had previously.
openaire +2 more sources
The geometry of SUSY enhancement [PDF]
Journal of High Energy Physics, 2020 Abstract We provide a precise geometric picture that demystifies the phenomenon of supersymmetry enhancement along certain RG flows of four-dimensional field theories, recently discovered by Maruyoshi and Song. It applies to theories of arbitrary rank and it is based on a hyperkähler-structure restoration on the moduli space of ...
Carta, Federico +3 more
openaire +9 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Two Types of Etiological Mutation in the Limb-Specific Enhancer of Shh
G3: Genes, Genomes, Genetics, 2017 An enhancer named MFCS1 regulates Sonic hedgehog (Shh) expression in the posterior mesenchyme of limb buds. Several mutations in MFCS1 induce ectopic Shh expression in the anterior limb bud, and these result in preaxial polydactyly (PPD).
Takanori Amano +3 more
doaj +1 more source
Epigenetics, 2022 Aberrant DNA methylation is an epigenetic hallmark of malignant tumours. The DNA methylation level is regulated by not only DNA methyltransferases (DNMTs) but also Ten-Eleven Translocation (TET) family proteins.
Ruitu Lyu +8 more
doaj +1 more source
Cell-specific expression of the FAP gene is regulated by enhancer elements
Frontiers in Molecular Biosciences, 2023 Fibroblast activation protein (FAP) is an integral membrane serine protease that acts as both dipeptidyl peptidase and collagenase. In recent years, FAP has attracted considerable attention due to its specific upregulation in multiple types of tumor cell
Dina V. Antonova +11 more
doaj +1 more source
Dynamic interplay between enhancer-promoter topology and gene activity
Nature Genetics, 2018 A long-standing question in gene regulation is how remote enhancers communicate with their target promoters, and specifically how chromatin topology dynamically relates to gene activation.
Hongtao Chen +5 more
semanticscholar +1 more source
Creating New β-Globin-Expressing Lentiviral Vectors by High-Resolution Mapping of Locus Control Region Enhancer Sequences. [PDF]
, 2020 Hematopoietic stem cell gene therapy is a promising approach for treating disorders of the hematopoietic system. Identifying combinations of cis-regulatory elements that do not impede packaging or transduction efficiency when included in lentiviral ...
Aleshe, Bamidele +14 more
core +1 more source
Reporter constructs with low background activity utilizing the cat gene [PDF]
, 1992 Reporter plasmids utilizing the cat gene for the analysis of promoter and enhancer sequences in vertebrate cells, were constructed. These plasmids minimize the background of transcription derived from cryptic promoters or cryptic regulatory elements ...
Andrea Schmidt +11 more
core +1 more source