Results 101 to 110 of about 5,668 (135)

METHIONINE ENKEPHALIN AND ISOSTERIC ANALOGUES

International Journal of Peptide and Protein Research, 1980
Biological activities are reported for two different types of analogues of methionine enkephalin. Cyclic analogues, bridged between the amino‐ and carboxy‐ terminals of the parent peptide, are inactive. In contrast, significant levels of activity are displayed by linear isosterically modified analogues in which the Tyr1 ‐Gly2 peptide bond is replaced ...
Robert Sharpe, Derek Hudson, Michael Szelke   +2 more
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Distribution of methionine-enkephalin in the minipig brainstem

Journal of Chemical Neuroanatomy, 2013
We have studied the distribution of immunoreactive cell bodies and axons are containing methionine-enkephalin in the minipig brainstem. Immunoreactive axons were widely distributed, whereas the distribution of perikarya was less widespread. A high or moderate density of axons containing methionine-enkephalin were found from rostral to caudal levels in ...
Rafael Coveñas, Elena Vecino, Manuel Lisardo Sánchez   +2 more
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Dopamine and methionine-enkephalin in human brain

Neuroscience Letters, 1982
Abstract The contents of dopamine (determined radioenzymatically) and methionine-enkephalin (assayed by a radioimmunoassay) were measured in several areas of the human brain. The peptide was principally localized in dopamine-rich structures. In patients with Parkinson's disease, in contrast to the general dopamine deficiency, the reduction in ...
Brigitte Berger, H. Taquet, François Cesselin, F. Javoy-Agid, A. Ploska, Yves Agid, M. Hamon, J.C. Legrand, Patricia Gaspar   +8 more
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Totalsynthese von Methionin‐Enkephalin

Angewandte Chemie, 1976
Zwanzigfache Normorphin‐Wirkung zeigt das aus Schweinehirn isolierte Pentapeptid (1), das man infolgedessen auch als „endogenes Opiat”︁ bezeichnet hat. Jetzt wird die Totalsynthese dieses Stoffes beschrieben magnified image.
Wolfgang Voelter, Emanuel Pietrzik, Claus Bürvenich, Hans Horn, Hubert Kalbacher   +4 more
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ENZYME IMMUNOASSAY FOR METHIONINE‐ENKEPHALIN SULFOXIDE

Clinical and Experimental Pharmacology and Physiology, 1990
SUMMARY1. An immunoassay technique employing an enzyme‐labelled ligand was developed for the sulfoxide derivative of the opioid peptide methionine‐enkephalin (MOE).2. The sensitivity of the enzyme immunoassay (EIA) was approximately twofold higher than that achieved in the radio‐immunoassay (RIA) using tritiated ligand.
Jean E. Olley, George K. L. Tiong
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Methionine Enkephalin: Clinical Pharmacology [PDF]

, 1986
Earlier studies indicated that methionine enkephalin infusions (1,000 micrograms) in normal volunteers induced facial flushing, general vasodilation and noisy stomach (borborgymi). Blood pressure and pulse rate were normal in all experiments. Plasma levels of pancreatic polypeptide, somatostatin, T3 and T4, TSH, FSH, PRL, ACTH, and GH were unchanged ...
R. Richter, J. L. Valentine, G. C. Miller, M. Fesen, Anthony J. Murgo, S. Solomon, L. Edwards, Robert E. Faith, N. P. Plotnikoff   +8 more
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Methionine‐enkephalin peptides in human teeth

International Journal of Peptide and Protein Research, 1988
The presence of the free opioid pentapeptide methionine enkephalin (ME) and of ME‐containing peptide(s) was established firmly in decalcified, depulped human teeth by using a combination of methods including RP‐HPLC, radioimmunoassay, radioreceptorassay, trypsin, carboxypeptidase B, fast atom bombardment mass spectrometry, and MS/MS methodology ...
Dominic M. Desiderio, Peter W. Tinsley, Francis S. Tanzer, Genevieve H. Fridland, John T. Killmar, Chhabil Dass, Emirgul Tolun   +6 more
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Synaptic mechanism of methionine-enkephalin uptake

Life Sciences, 1982
The actions of classical neurotransmitters at the synapse are rapidly terminated either by re-uptake or by enzymatic degradation. Enkephalins, like other neurotransmitters, have been demonstrated to be degraded by active proteinases present in the brain. However, it has been generally assumed that an uptake process is not operant for met-enkephalin. To
J. Go, I. Jamal, B.P. Roy
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Cross tolerance between morphine and methionine-enkephalin [PDF]

Nature, 1976
TOLERANCE and dependence are characteristic symptoms in man during prolonged use of opiates. We have pointed out1 that for an understanding of these phenomena the interaction between endogenous enkephalin and exogenous opiates is of importance. Normally, enkephalin can be assumed to control inhibitory mechanisms determining the rate of neurotransmitter
Hans W. Kosterlitz, Angela A. Waterfield, John Hughes   +2 more
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Influence of Ethanol Dependence and Methionine Enkephalin Antisense on Serum Endomorphin‐1 and Methionine Enkephalin Levels

Alcoholism: Clinical and Experimental Research, 2004
Abstract: Background: Opiate peptides are involved in the physical dependence on ethanol. Levels of methionine enkephalin (MEnk), for example, are affected by ethanol. No study on the effect of ethanol on endomorphin, the endogenous ligand for the μ‐opiate receptor, has yet been conducted.Methods: We examined the effect of ethanol ingestion on serum
John E. Morley, Vijaya B. Kumar, William A. Banks   +2 more
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