Results 101 to 110 of about 5,741 (136)

Dopamine and methionine-enkephalin in human brain

Neuroscience Letters, 1982
Abstract The contents of dopamine (determined radioenzymatically) and methionine-enkephalin (assayed by a radioimmunoassay) were measured in several areas of the human brain. The peptide was principally localized in dopamine-rich structures. In patients with Parkinson's disease, in contrast to the general dopamine deficiency, the reduction in ...
A, Ploska, H, Taquet, F, Javoy-Agid, P, Gaspar, F, Cesselin, B, Berger, M, Hamon, J C, Legrand, Y, Agid   +8 more
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ENZYME IMMUNOASSAY FOR METHIONINE‐ENKEPHALIN SULFOXIDE

Clinical and Experimental Pharmacology and Physiology, 1990
SUMMARY1. An immunoassay technique employing an enzyme‐labelled ligand was developed for the sulfoxide derivative of the opioid peptide methionine‐enkephalin (MOE).2. The sensitivity of the enzyme immunoassay (EIA) was approximately twofold higher than that achieved in the radio‐immunoassay (RIA) using tritiated ligand.
G K, Tiong, J E, Olley
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Methionine‐enkephalin peptides in human teeth

International Journal of Peptide and Protein Research, 1988
The presence of the free opioid pentapeptide methionine enkephalin (ME) and of ME‐containing peptide(s) was established firmly in decalcified, depulped human teeth by using a combination of methods including RP‐HPLC, radioimmunoassay, radioreceptorassay, trypsin, carboxypeptidase B, fast atom bombardment mass spectrometry, and MS/MS methodology ...
F S, Tanzer, E, Tolun, G H, Fridland, C, Dass, J, Killmar, P W, Tinsley, D M, Desiderio   +6 more
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Synaptic mechanism of methionine-enkephalin uptake

Life Sciences, 1982
The actions of classical neurotransmitters at the synapse are rapidly terminated either by re-uptake or by enzymatic degradation. Enkephalins, like other neurotransmitters, have been demonstrated to be degraded by active proteinases present in the brain. However, it has been generally assumed that an uptake process is not operant for met-enkephalin. To
B P, Roy, I, Jamal, J, Go
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Influence of Ethanol Dependence and Methionine Enkephalin Antisense on Serum Endomorphin‐1 and Methionine Enkephalin Levels

Alcoholism: Clinical and Experimental Research, 2004
Abstract: Background: Opiate peptides are involved in the physical dependence on ethanol. Levels of methionine enkephalin (MEnk), for example, are affected by ethanol. No study on the effect of ethanol on endomorphin, the endogenous ligand for the μ‐opiate receptor, has yet been conducted.Methods: We examined the effect of ethanol ingestion on serum
William A, Banks, Vijaya B, Kumar, John E, Morley   +2 more
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METHIONINE ENKEPHALIN AND ISOSTERIC ANALOGUES

International Journal of Peptide and Protein Research, 1980
Biological activities are reported for two different types of analogues of methionine enkephalin. Cyclic analogues, bridged between the amino‐ and carboxy‐ terminals of the parent peptide, are inactive. In contrast, significant levels of activity are displayed by linear isosterically modified analogues in which the Tyr1 ‐Gly2 peptide bond is replaced ...
DEREK HUDSON, ROBERT SHARPE, MICHAEL SZELKE   +2 more
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Totalsynthese von Methionin‐Enkephalin

Angewandte Chemie, 1976
Zwanzigfache Normorphin‐Wirkung zeigt das aus Schweinehirn isolierte Pentapeptid (1), das man infolgedessen auch als „endogenes Opiat”︁ bezeichnet hat. Jetzt wird die Totalsynthese dieses Stoffes beschrieben magnified image.
Wolfgang Voelter, Claus Bürvenich, Hans Horn, Hubert Kalbacher, Emanuel Pietrzik   +4 more
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Methionine–enkephalin related glycoconjugates

International Journal of Peptide and Protein Research, 1993
A series of glycoconjugates, in which [Met5]enkephalin or [d‐Ala2, Met5]enkephalin have been linked through an ester bond to the HO‐6 of various d‐glycopyranose moieties, were synthesized by classical solution methods. The biological activities of these compounds were determined on selective pharmacological preparations: guinea pig ileum and mouse vas ...
Š. HORVAT, J. HORVAT, L. VARGA‐DEFTERDAROVIĆ, K. PAVELIĆ, N.N. CHUNG, P.W. SCHILLER   +5 more
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Plasma Methionine-Enkephalin and Leucine-Enkephalin in Normal Subjects and Patients with Pheochromocytoma*

The Journal of Clinical Endocrinology & Metabolism, 1983
Plasma methionine-enkephalin-like and leucine-enkephalin-like immunoreactivity (met-enkephalin-LI and leu-enkephalin-LI, respectively) in six normal subjects and six patients with pheochromocytoma were determined. The contents of met-enkephalin-LI and leu-enkephalin-LI in two of six pheochromocytomas were 40- to 50-fold higher and those in the other ...
T, Yoshimasa, K, Nakao, S, Li, Y, Ikeda, M, Suda, M, Sakamoto, H, Imura   +6 more
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Effect of methionine-enkephalin on xanthophore aggregation

Peptides, 1980
The intracranial injection of an opioid antagonist (naloxone) caused aggregation of xanthophores in goldfish scales. This aggregating effect produced by naloxone was inhibited by an injection of methionine-enkephalin (M-ENK). M-ENK, when injected together with melatonin which normally produces aggregation of xanthophores, interfered with the effect of ...
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