Results 1 to 10 of about 20,669 (211)

THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES [PDF]

British Journal of Pharmacology, 1977
A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.Over 90% of the opioid peptide activity isolated from ...
J, Hughes, H W, Kosterlitz, T W, Smith
openaire   +4 more sources

‘Acetaldehyde‐enkephalins’: elucidation of the structure of the acetaldehyde adducts of methionine‐enkephalin and leucine‐enkephalin [PDF]

FEBS Letters, 1980
The two major endogenous opioid pentapeptides, methionine-enkephalin and leucine-enkephalin [ 1,2] rapidly react with acetaldehyde, under very mild conditions, to give an ‘acetaldehyde-enkephalin’ adduct, referred to as ‘acetaldehyde-enkephalin [Met’] and ‘acetaldehyde-enkephalin [Leu”], respectively 231.
Summers, Michael C., Gidley, Michael J., Sanders, Jeremy K.   +2 more
openaire   +4 more sources

MALDI-induced fragmentation of leucine enkephalin, nitro-Tyr-leucine enkaphalin, and d5-Phe-nitro-Tyr-leucine enkephalin [PDF]

International Journal of Mass Spectrometry, 2009
The long-term objective of this study is to use MALDI MS and MS/MS to study the fragmentation pattern of in vitro nitrotyrosine-containing peptides in order to assist the interpretation of MS-identification of endogenous nitroproteins in human tissues and fluids.
Xianquan, Zhan, Dominic M, Desiderio
openaire   +2 more sources

Degrees of freedom effect on fragmentation in tandem mass spectrometry of singly charged supramolecular aggregates of sodium sulfonates [PDF]

, 2013
The characteristic collision energy (CCE) to obtain 50% fragmentation of positively and negatively single charged non-covalent clusters has been measured.
Bongiorno, David, Ceraulo, Leopoldo, Drahos, László, Indelicato, Serena, Indelicato, Sergio, Liveri, Vincenzo Turco, Turiák, Lilla, Vékey, Károly   +7 more
core   +2 more sources

Three protected tetrapeptides [PDF]

, 1996
The structures of three protected tetrapeptides, containing the Boc-Gly-Gly-Phe-X-OMe chain, tert-butoxycarbonyl-glycy-glycl-phenylalanine-leucine methyl ester dihydrate, Boc-Gly-Gly-L-Phe-D-Leu-OMe, C25H38N4O7·2H2O, tert-butoxycarbonyl-glycy-glycl ...
Casalone, Gianluigi, Fenude, Emma
core   +1 more source

Acetaldehyde‐enkephalins: pronounced changes in the opiate activity of methionine‐enkephalin and leucine‐enkephalin on reaction with acetaldehyde [PDF]

FEBS Letters, 1980
We have shown that the two major endogenous opioid peptides, methionine-enkephalin and leucineenkephalin [ 1,2] (enkephalin [Met’] and enkephalin[Leu’]) rapidly react with acetaldehyde in aqueous buffers to give a stable ‘acetaldehyde-enkephalin’ adduct, referred to as ‘acetaldehyde-enkephalin[Met’]’ and ‘acetaldehyde-enkephalin [Leu’]‘, respectively ...
Summers, Michael C., Hayes, Roger J.
openaire   +2 more sources

New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger's Disease) [PDF]

, 1984
The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected.
Berlit, Peter, Kessler, C., Krause, Klaus-Henning, Reuther, R.   +3 more
core   +1 more source

Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1–17) on neocortical neurons in vitro [PDF]

, 1984
Intracellular recordings were made from neocortical neurons in vitro. Application of D-Ala2-D-Leu5-enkephalin (DADL) by different methods produced a decrease in EPSP amplitude and in the amplitude of L-glutamate-induced depolarizations without changes in
B Sutor, Khachaturian, Lewis, Quirion, Satoh, W Zieglgänsberger, Weber, Williams, Williams, Yoshimura, Zieglgänsberger, Zieglgänsberger   +11 more
core   +1 more source

Photodissociation spectroscopy of protonated leucine enkephalin

Physical Chemistry Chemical Physics, 2017
The protonated pentapeptide leucine enkephaline (YGGFL) fragments upon absorption of multiple UV photons by the tyrosine chromophore, providing complete sequence coverage.
Andreas Herburger, Christian van der Linde, Martin K. Beyer   +2 more
openaire   +3 more sources

Direct peptide bioconjugation/PEGylation at tyrosine with linear and branched polymeric diazonium salts [PDF]

, 2012
Direct polymer conjugation at peptide tyrosine residues is described. In this study Tyr residues of both leucine enkephalin and salmon calcitonin (sCT) were targeted using appropriate diazonium salt-terminated linear monomethoxy poly(ethylene glycol)s ...
Aghemo A., Aurora J., Ban H., Brocchini S., Brown J. P., Canevari M., Chesnut C. H., Claudia A. Blindauer, Curreli N., David J. Brayden, David M. Haddleton, DeTraglia M. C., Duncan R., Edgcomb S. P., Epand R. M., Espuna G., Fishburn C. S., Gao W., Giuseppe Mantovani, Gorecki M., Hooker J. M., Howard A. N., Jain A., Jain R. K., Joshi N. S., Kato M., Kopecek J., Kopecek J., Lecolley F., Lee K. C., Lele B. S., Lele B. S., Li K., Magnusson J. P., Mantovani G., Mathew W. Jones, McFarland J. M., Ouchi M., Patai S., Patai S., Pauly H. Z., Rafii F., Roberts M. J., Romanini D. W., Ryan S. M., Sams C. F., Sayers C. T., Sayers C. T., Schalk I., Schlick T. L., Sinead M. Ryan, Southam R. M., Szurdoki F., Tao L., Tilley S. D., Tracey B. M., Vaughan K., Veronese F. M., Vilaro M., Wang J.-S., White E. H., Wong S. S., Xuexuan Wang, Yasayan G., Zloh M.   +64 more
core   +1 more source