Results 41 to 50 of about 16,221 (164)

Untargeted Metabolomics Reveals Seasonal and Tissue‐Specific Metabolic Shifts in Holothuria cinerascens

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
Untargeted metabolic profiling of three body tissues from Holothuria cinerascens in South Africa using 1H‐NMR and UPLC–QTOF–MS revealed distinct tissue‐specific and seasonal metabolic variations, with the body wall and gut/mesentery exhibiting high metabolite diversity.
Cassandra Upton, Gerhard Prinsloo, Paul Steenkamp, Moses Okpeku   +3 more
wiley   +1 more source

Unveiling the Molecular Profile and Antiviral Potential of Costus arabicus L. Against Zika Virus

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
Analysis of the chemical profile and antiviral potential of Costus arabicus L. extracts. ABSTRACT Widely used in Brazilian folk medicine, Costus arabicus L. (Canarana) is a herbaceous plant with promising pharmacological potential. Here, we profile the molecular composition of extracts from different plant organs and evaluate their in vitro activity ...
Alice Rhelly V. Carvalho, José Diogo E. Reis, Ariane Coelho Ferraz, Marília Bueno da Silva Menegatto, Juliana da C. Lopes, Sônia das G. S. R. Pamplona, Milton N. da Silva, Cintia Lopes de Brito Magalhães, Paulo Wender P. Gomes, Consuelo Yumiko Yoshioka e Silva   +9 more
wiley   +1 more source

Linking Metabolomic Diversity to Pharmacological Potency in Anonidium mannii Leaf Extracts

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
This study investigates the metabolomic profile and pharmacological activities of extracts from Anonidium mannii leaves. The extracts were profiled using an integrated LC‐MS/GC‐MS, and evaluated for antimicrobial, antioxidant and cytotoxic activities, providing a basis for future studies and validation in more advanced biological models.
Olusesan Ojo, Garland K. More, Gerhard Prinsloo   +2 more
wiley   +1 more source

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

Small, Volume 22, Issue 8, 6 February 2026.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad, Shunping Han, Rifka Utami, Rafal Baker, Dina Helal, Zhuoni Li, Mark Tricklebank, Yannis Paloyelis, Julie Wang, Marija M. Petrinovic, Sukhi Bansal, Khuloud T. Al‐Jamal   +11 more
wiley   +1 more source

Flavin Biosynthesis Enhances Extracellular Electron Transfer in Bioengineered Escherichia coli

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Microbial electronics are promising for energy, sensing, environmental, and synthesis applications. E. coli are engineered with extracellular electron transfer (EET) pathways from a microbe that naturally produces current to enable bioelectronics based on E. coli.
Mohammed Mouhib, Melania Reggente, Hanxuan Wang, Charlotte Roullier, Ardemis A. Boghossian   +4 more
wiley   +1 more source

UHPLC‐MSE Insights Into Extrusion‐Driven Changes in Wheat Phenolics and Their Bioaccessibility

Cereal Chemistry, Volume 103, Issue 1, Page 124-134, January/February 2026.
ABSTRACT Background and Objectives This study evaluated the impact of thermoplastic extrusion (wheat snack, WS) and cold extrusion followed by cooking (wheat pasta, WP) on phenolic compounds (PC) in two Brazilian wheat genotypes, commercially classified by gluten strength (ORS Agile, strong; ORS Vintecinco, weak).
Renata Marenda Ferreira, Carolina Thomaz Dos Santos D'Almeida, Thais Oliveira de Alves, Carlos Wanderlei Piler de Carvalho, Cristina Yoshie Takeiti, Mariana Simões Larraz Ferreira   +5 more
wiley   +1 more source

Research of the analgesic effects and central nervous system impact of electroacupuncture therapy in rats with knee osteoarthritis

Heliyon
It aimed to observe the effects of TongDu TiaoShen (TDTS) electroacupuncture (EA) on the analgesia and central system of knee osteoarthritis (KOA) rats and explore its mechanism. SD rats were rolled into the blank group, model group (KOA), control group (
Xiahai Zheng, Jing Lin, Zhenzhen Wang, Zhenming Zeng, Haoxiong Chen   +4 more
doaj   +1 more source

Functionalized Donor–π–Acceptor (D–π–A) Organic Linkers for Metal–Organic Frameworks with Extended Visible‐Light Absorption

Chemistry–Methods, Volume 6, Issue 1, January 2026.
Triphenylamine‐based dyes L0‐TA and L1‐TA are synthesized and electrochemically characterized to assess their suitability for photocatalytic hydrogen production via water splitting. Crystallographic simulations confirm their structural compatibility with the MIL‐125 framework, allowing incorporation without steric clashes.
Giorgia Salerno, Claudia Favia, Aurelia Falcicchio, Rocco Caliandro, Norberto Manfredi, Alessandro Abbotto, Ottavia Bettucci   +6 more
wiley   +1 more source

Lipidomic Comparison of Detergent‐Soluble and Detergent‐Resistant Lipid Domains Isolated From Rat Cerebellum and the Effect of Hypoxia–Ischemia Using UPLC‐HDMSE

Journal of Mass Spectrometry, Volume 61, Issue 1, January 2026.
ABSTRACT Hypoxic ischemic encephalopathy (HIE) due to insufficient oxygen or blood flow to the brain can result in inflammation, impaired neurodevelopment, or death. Changes to microdomain lipid composition may contribute to altered structure and function of key regulatory processes; however, knowledge regarding changes to membrane lipid composition ...
Samuel A. Krug, Min He, Ningfeng Tang, Cynthia Bearer, Maureen A. Kane   +4 more
wiley   +1 more source

Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat

The FEBS Journal, Volume 293, Issue 2, Page 475-491, January 2026.
Inhibition of angiotensin I‐converting enzyme is an effective strategy for the treatment of hypertension. However, the clinically available ACE inhibitors cause side effects due to nonselective inhibition of the two catalytic domains of ACE (nACE and cACE).
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source