Results 41 to 50 of about 16,517 (164)

Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein citrullination, driven by peptidyl arginine deiminases (PAD2, PAD4), is linked to multiple diseases. Using a combinatorial peptide library and advanced mass spectrometry, we reveal distinct substrate selectivity profiles of PAD2 and PAD4. While PAD2 broadly citrullinates arginine‐containing peptides, PAD4 is highly sequence‐restricted, with ...
Adina Borbély, Arnold Steckel, Dávid Papp, Domonkos Pál, Katalin Uray, Viktória Goldschmidt Gőz, Gitta Schlosser   +6 more
wiley   +1 more source

Advantages of Alkali Metal Adduct Formation in Cyclic Ion Mobility‐Mass Spectrometry of O‐Methylated Cyclodextrin Isomers—Separation and Crossring Fragmentation

Chemistry–Methods, Volume 6, Issue 6, June 2026.
Cyclic ion mobility–tandem mass spectrometry (cIM‐MS/MS) enables rapid differentiation of O‐methylated cyclodextrin (MeCD) regioisomers. The method separates 2,3‐ and 2,6‐DIMEB (heptakis‐2,3‐ and ‐2,6‐di‐O‐methyl‐β‐cyclodextrins) and identifies them via characteristic crossring fragmentation.
Péter Soma Szakály, Arnold Steckel, Dávid Papp, Erzsébet Varga, Gitta Schlosser   +4 more
wiley   +1 more source

The competitive interplay of 12‐oxophytodienoic acid (OPDA), protein thiols, and glutathione

The FEBS Journal, Volume 293, Issue 12, Page 3683-3705, June 2026.
12‐Oxophytodienoic acid (OPDA) is a phytohormone involved in plant growth and stress defense. Due to its cyclopentenone moiety, OPDA can form Michael adducts with thiol‐containing compounds such as glutathione and cysteine residues of proteins, resulting in alterations of the cellular redox regulatory network.
Madita Knieper, Ruben Schwarz, Lara Vogelsang, Jens Sproß, Armağan Kaya, Maike Bittmann, Harald Gröger, Andrea Viehhauser, Karl‐Josef Dietz   +8 more
wiley   +1 more source

New analogues of leucine-methionine-enkephalin

Journal of Biosciences, 1988
Nine analogues of the opioid pentapeptides leucine-/ methionine-enkephalinamide, involving replacement of amino acid at position 5 or amino acids at positions 2 and 5, have been synthesized by the solid phase method using mainly 9-fluorenylmethyloxycarbonyl amino acid trichlorophenyl esters in the presence of 1-hydroxybenzotriazole, the solid support ...
Sivanandaiah, K.M., Gurusiddappa, S., Channegowda, C.   +2 more
openaire   +2 more sources

Cedrela fissilis Vell. Inner Bark: LC–MS/MS‐Based Chemical Profiling and Toxicological Effects

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
ABSTRACT Investigating the mechanistic toxicity of plant extracts is essential for safety assessment. The predictive toxicological effects of Cedrela fissilis were evaluated, and LC–MS/MS‐based chemical profiling was performed. The hydroethanolic extract (HeECf) and ethyl acetate (EA) fraction were assessed in multimodel systems with different levels ...
Thainá Pereira da Silva Cabral, Emanuel Victor dos Santos Nunes, Viviani de Brito Massad Gomes da Silva, Fhelipe Jolner Souza de Almeida, Douglas Lisboa Ramalho, Jadyellen Rondon Silva, Anderson de Oliveira Souza, Maria Cristina Fuzari Bezerra, Ian Castro‐Gamboa, Helder Lopes Teles, Mayara Peron Pereira   +10 more
wiley   +1 more source

Nutritional Interventions and Acupuncture‐Based Strategies for Exercise‐Induced Fatigue and Recovery: Mechanisms and Integrative Perspectives

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Excessive exercise induces exercise‐induced fatigue through multiple interconnected mechanisms, including energy shortage and metabolite accumulation, oxidative stress and inflammation, mitochondrial dysfunction, and neuroendocrine strain. Integrative management strategies include nutrition‐based approaches and acupuncture‐based interventions ...
Yaqin Yang, Yao Yao, Weiyu Lu, Jiazhou Li, Lijuan Zou, Huashan Pan   +5 more
wiley   +1 more source

Innate Lymphoid Cells in Tissue Homeostasis and Diseases

MedComm, Volume 7, Issue 5, May 2026.
Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan, Heyang Sun, Chenning Li, Qianya Hong, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source

A Stepwise Approach to 1,4,10,13‐Tetraaza‐18‐Crown‐6 Ether

ChemistryOpen, Volume 15, Issue 5, May 2026.
A two‐step synthetic strategy to tetraaza‐18‐crown‐6 was developed to overcome the low yield of the conventional one‐step method. Optimized conditions significantly suppressed formation of the undesired nine‐membered ring. A three‐fold increase in yield of the macrocyclization step was obtained, or two‐fold when column chromatography was avoided. A two‐
Pieter Troosters, Lara Bruneel, Wim Dehaen, Tomas Opsomer   +3 more
wiley   +1 more source

Research of the analgesic effects and central nervous system impact of electroacupuncture therapy in rats with knee osteoarthritis

Heliyon
It aimed to observe the effects of TongDu TiaoShen (TDTS) electroacupuncture (EA) on the analgesia and central system of knee osteoarthritis (KOA) rats and explore its mechanism. SD rats were rolled into the blank group, model group (KOA), control group (
Xiahai Zheng, Jing Lin, Zhenzhen Wang, Zhenming Zeng, Haoxiong Chen   +4 more
doaj   +1 more source

Mass Spectrometry Imaging Combined With Single‐Cell Transcriptional Profiling Reveals the Multidimensional Spatial Distributions and Biosynthetic Pathways of Medicinal Components in Andrographis paniculata

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2876-2890, May 2026.
ABSTRACT The synthesis and accumulation of active ingredients in medicinal plants are distributed in specific organs, tissues, and cell types, which are important for the exploitation of medicinal plants. However, the fine distribution of active ingredients is difficult to know. Here, the system of mass spectrometry imaging (MSI) integrated with single‐
HaiSheng Zeng, MeiHui Shi, ZhiRong Chen, XueJing Sun, HuiJie Zhang, Yue Huang, YuCheng Chen, Jun Ren, HuiLing Huang, Almaz Borjigidai, Man Zhang, SuJuan Duan, Yi‐Jun Chen, Hong‐Lei Jin, Hong‐Bin Wang   +14 more
wiley   +1 more source