Results 21 to 30 of about 16,221 (164)

Neuroprotective and neuroregenerative potential of pharmacologically-induced hypothermia with D-alanine D-leucine enkephalin in brain injury

Neural Regeneration Research, 2018
Neurovascular disorders, such as traumatic brain injury and stroke, persist as leading causes of death and disability – thus, the search for novel therapeutic approaches for these disorders continues.
M Grant Liska, Marci G Crowley, Julian P Tuazon, Cesar V Borlongan   +3 more
doaj   +1 more source

Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma. [PDF]

Journal of Clinical Investigation, 1982
To elucidate the physiological and pathophysiological significance of methionine- and leucine-enkephalin (Met-and Leu-enkephalin, respectively) in human sympathoadrenal system, the contents of these peptides in normal human sympathetic nervous system, adrenal medulla, and pheochromocytomas were determined by specific radioimmunoassays combined with ...
T, Yoshimasa, K, Nakao, H, Ohtsuki, S, Li, H, Imura   +4 more
openaire   +2 more sources

Metal-Binding Ability of Leu-Enkephalin, Related Glycoconjugates and Peptidomimetics

Croatica Chemica Acta, 2015
Both the chemistry and consequences of the nonenzymatic reaction between reducing sugars and reactive amino groups of amino acids, peptides and proteins (known as the Maillard reaction), have received considerable attention in food and health science ...
Zsuzsa Majer, Elemér Vass, Maja Roščić, Miklós Hollósi, Štefica Horvat, Andreja Jakas   +5 more
doaj   +1 more source

An Immunocytochemical Study of Endocrine Cells in the Gut of a Stomachless Teleost Fish, Grass Carp, Cyprinidae

Cell Transplantation, 1993
Nineteen different antisera raised against mammalian hormones were used to identify the occurrence and distribution of endocrine cells in the gut of grass carp (Ctenopharyngodon idellus).
Qian-Sheng Pan, Zhi-Ping Fang
doaj   +1 more source

New analogues of leucine-methionine-enkephalin

Journal of Biosciences, 1988
Nine analogues of the opioid pentapeptides leucine-/ methionine-enkephalinamide, involving replacement of amino acid at position 5 or amino acids at positions 2 and 5, have been synthesized by the solid phase method using mainly 9-fluorenylmethyloxycarbonyl amino acid trichlorophenyl esters in the presence of 1-hydroxybenzotriazole, the solid support ...
Sivanandaiah, K.M., Gurusiddappa, S., Channegowda, C.   +2 more
openaire   +2 more sources

THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES [PDF]

British Journal of Pharmacology, 1977
A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.Over 90% of the opioid peptide activity isolated from ...
J, Hughes, H W, Kosterlitz, T W, Smith
openaire   +4 more sources

Acetaldehyde‐enkephalins: pronounced changes in the opiate activity of methionine‐enkephalin and leucine‐enkephalin on reaction with acetaldehyde [PDF]

FEBS Letters, 1980
We have shown that the two major endogenous opioid peptides, methionine-enkephalin and leucineenkephalin [ 1,2] (enkephalin [Met’] and enkephalin[Leu’]) rapidly react with acetaldehyde in aqueous buffers to give a stable ‘acetaldehyde-enkephalin’ adduct, referred to as ‘acetaldehyde-enkephalin[Met’]’ and ‘acetaldehyde-enkephalin [Leu’]‘, respectively ...
Summers, Michael C., Hayes, Roger J.
openaire   +2 more sources

The competitive interplay of 12‐oxophytodienoic acid (OPDA), protein thiols, and glutathione

The FEBS Journal, EarlyView.
12‐Oxophytodienoic acid (OPDA) is a phytohormone involved in plant growth and stress defense. Due to its cyclopentenone moiety, OPDA can form Michael adducts with thiol‐containing compounds such as glutathione and cysteine residues of proteins, resulting in alterations of the cellular redox regulatory network.
Madita Knieper, Ruben Schwarz, Lara Vogelsang, Jens Sproß, Armağan Kaya, Maike Bittmann, Harald Gröger, Andrea Viehhauser, Karl‐Josef Dietz   +8 more
wiley   +1 more source

Mass Spectrometry Imaging Combined With Single‐Cell Transcriptional Profiling Reveals the Multidimensional Spatial Distributions and Biosynthetic Pathways of Medicinal Components in Andrographis paniculata

Plant Biotechnology Journal, EarlyView.
ABSTRACT The synthesis and accumulation of active ingredients in medicinal plants are distributed in specific organs, tissues, and cell types, which are important for the exploitation of medicinal plants. However, the fine distribution of active ingredients is difficult to know. Here, the system of mass spectrometry imaging (MSI) integrated with single‐
HaiSheng Zeng, MeiHui Shi, ZhiRong Chen, XueJing Sun, HuiJie Zhang, Yue Huang, YuCheng Chen, Jun Ren, HuiLing Huang, Almaz Borjigidai, Man Zhang, SuJuan Duan, Yi‐Jun Chen, Hong‐Lei Jin, Hong‐Bin Wang   +14 more
wiley   +1 more source

Antinociceptive Effect of Intrathecal Injection of Genetically Engineered Human Bone Marrow Stem Cells Expressing the Human Proenkephalin Gene in a Rat Model of Bone Cancer Pain

Pain Research and Management, 2017
Background. This study aimed to investigate the use of human bone marrow mesenchymal stem cells (hBMSCs) genetically engineered with the human proenkephalin (hPPE) gene to treat bone cancer pain (BCP) in a rat model. Methods. Primary cultured hBMSCs were
Yi Sun, Yuke Tian, Haifeng Li, Dengwen Zhang, Qiang Sun   +4 more
doaj   +1 more source