Results 51 to 60 of about 79,525 (194)

UPLC‐QTOF‐MS/MS and Antifungal Activity of a Fraction Enriched in Saponins From Sarcomphalus joazeiro Against Candida spp

Biomedical Chromatography, Volume 40, Issue 7, July 2026.
ABSTRACT The development of antifungal resistance is a complex process that involves the interaction between hosts, drugs, and microbial factors, all of which contribute to therapeutic ineffectiveness. For this reason, studies on natural products as possible therapeutic alternatives are increasingly necessary in order to gain a better understanding of ...
Ana Raquel Pereira da Silva, Maria do Socorro Costa, Nara Juliana Santos Araújo, Gabriel Gonçalves Alencar, Talysson Felismino Moura, Victor Juno Alencar Fonseca, Antônia Thassya Lucas dos Santos, Maria Flaviana Bezerra Morais‐Braga, Erlânio Oliveira de Souza, Josean Fechine Tavares, Paulo Riceli Vasconcelos Ribeiro, Jacqueline Cosmo Andrade‐Pinheiro, Henrique Douglas Melo Coutinho   +12 more
wiley   +1 more source

Decoding Biothreats With FT‐ICR‐MS: Metabotyping of Bacillus cereus Spores Through Untargeted Metabolomics

Journal of Mass Spectrometry, Volume 61, Issue 7, July 2026.
ABSTRACT Genome sequencing is the gold standard for microbial identification. However, it fails to distinguish closely related species with overlapping genetic features. This is the case of Bacillus cereus and Bacillus cytotoxicus, two members of the B. cereus group with distinct pathogenic profiles. While B. cereus, a well‐known opportunistic pathogen
Maria Inês Romão, Inês Gomes, Wilson Antunes, Petr Novak, Marta Sousa Silva, Carlos Cordeiro   +5 more
wiley   +1 more source

Potentiometric, calorimetric and spectroscopic study of copper(II) complexes of leucine-enkephalin and tripeptides containing tyrosine

, 2017
Complexation of Copper(II) ion with three peptides containing tyrosine residue (Gly-Gly-L-Tyr, L-Tyr-Gly-Gly and Leucine-enkephalin) was studied by pH-metric, visible spectroscopic measurements at 25°C and 0.2 mol dm-3KNO3, e.s.r spectra and calorimetric
G Lapluye, M Jouini, B Mrabet, J Huet
core   +1 more source

Opioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-laboring myometrium [PDF]

, 2013
The existence of opioid receptors in mammalian myometrial tissue is now widely accepted. Previously enkephalin degrading enzymes have been shown to be elevated in pregnant rat uterus and a met-enkephalin analogue has been shown to alter spontaneous ...
McMorrow, Jason P., Carey, Michael F., Campion, Deirdre P., O\u27Connor, J. J., Fanning, Rebecca A., O'Connor, J. J.   +5 more
core   +1 more source

The Metabolic Awakening of Barley Seedlings: A Time‐Resolved View of How Germination and Light Shape Tissue‐Specific Metabolic Networks

Plant Direct, Volume 10, Issue 7, July 2026.
ABSTRACT Integration of internal metabolism with environmental cues is essential for successful establishment and survival of seedlings, with light an important mediator of the transition from skotomorphogenesis to photomorphogenesis. However, detailed knowledge of the metabolic events associated with this critical transition in developing tissues of ...
Claude Y. Hamany Djande, Paul A. Steenkamp, Ian A. Dubery   +2 more
wiley   +1 more source

New analogues of leucine-methionine-enkephalin

Journal of Biosciences, 1988
Nine analogues of the opioid pentapeptides leucine-/ methionine-enkephalinamide, involving replacement of amino acid at position 5 or amino acids at positions 2 and 5, have been synthesized by the solid phase method using mainly 9-fluorenylmethyloxycarbonyl amino acid trichlorophenyl esters in the presence of 1-hydroxybenzotriazole, the solid support ...
Sivanandaiah, K.M., Gurusiddappa, S., Channegowda, C.   +2 more
openaire   +2 more sources

The enzymatic degradation and transport of leucine–enkephalin and 4-imidazolidinone enkephalin prodrugs at the blood–brain barrier

, 1998
In this study, the stability in and transport across a cell culture model of the blood-brain barrier (BBB) is investigated for leucine-enkephalin (Leu-enkephalin) and four 4-imidazolidinone prodrugs of Leu-enkephalin. The results show that Leu-enkephalin
G.J Friis, L Lund, Bak, A., L Hovgaard, Lund, L., Friis, G.J., L.L Christrup, Christrup, Lona Louring, A Bak, Hovgaard, L.   +9 more
core   +1 more source

Structural basis of regioselective double halogenation of the β‐carboline tryptoline by the single‐component halogenase AetF

Acta Crystallographica Section D, Volume 82, Issue 7, Page 836-844, July 2026.
A structure of the flavin‐dependent single‐component tryptophan halogenase AetF bound to the non‐native tricyclic substrate tryptoline reveals a binding pose analogous to l‐tryptophan that directs C6‐first halogenation. Product analysis identifies 6,8‐dibromotryptoline as the final product.Flavin‐dependent halogenases (FDHs) offer a biocatalytic route ...
Simon Bork, Hendrik J. Horstmeier, Bjarne Scharkowski, Hartmut H. Niemann   +3 more
wiley   +1 more source

High field asymmetric waveform ion mobility spectrometry–mass spectrometry: an investigation of leucine enkephalin ions produced by electrospray ionization [PDF]

, 1999
High field asymmetric waveform ion mobility spectrometry (FAIMS) provides atmospheric pressure, room temperature, low-resolution separation of gas-phase ions.
Guevremont, Roger, Purves, Randy W
core   +1 more source

Liver‐ and Immune‐Enriched Molecular Signatures Associated With Mortality in Older Adults

Aging Cell, Volume 25, Issue 7, July 2026.
Untargeted plasma proteomics and metabolomics identified molecular signatures associated with all‐cause mortality in older adults. A liver‐enriched proteomic profile was associated with mortality risk in the ILAS cohort and showed consistent associations in an independent validation cohort, supporting circulating proteomic profiles for mortality risk ...
Yi‐Long Huang, Wei‐Ju Lee, Pei‐Lin Lee, Li‐Ning Peng, Fei‐Yuan Hsiao, Liang‐Kung Chen   +5 more
wiley   +1 more source