Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen +11 more
wiley +1 more source
Double labelling immunohistochemical characterization of autonomic sympathetic neurons innervating the sow retractor clitoridis muscle [PDF]
Retrograde neuronal tracing and immunohistochemical methods were used to define the neurochemical content of sympathetic neurons projecting to the sow retractor clitoridis muscle (RCM). Differently from the other smooth muscles of genital organs, the RCM
Acone, Franca +6 more
core
Use of quadrupole time-of-flight mass spectrometry for proposal of transformation products of the herbicide bromacil after water chlorination [PDF]
The herbicide bromacil has been extensively used in the Spanish Mediterranean region, and although plant protection products containing bromacil have been withdrawn by the European Union, this compound is still frequently detected in surface and ground ...
Hernandez, Felix +3 more
core +3 more sources
Untargeted metabolomics and lipidomics integrated with two‐sample bidirectional Mendelian randomization identified hexanoylglycine and LPC (16:0) as obesity‐associated biomarkers. Hexanoylglycine and LPC (16:0) showed potential causal links to BMI, were partially mediated by immune cell traits, and were associated with blood pressure, indicating ...
Mahan Si +5 more
wiley +1 more source
This study optimized cold and hot water extractions for maximizing phenolic content and antibacterial activity against S. aureus and P. aeruginosa. Hot water yielded higher total phenolics and were more effective against P. aeruginosa. Conversely, cold water enriched specific ellagitannins (punicalagin and cistusin), showing potent, targeted ...
Atalanti Christou +9 more
wiley +1 more source
CD and FTIR Spectroscopic Studies of Carbohydrate-modified Opioid Peptides [PDF]
The variety of vital functions played by glycoproteins in many physiological and pathological processes inspired the design of glycopeptides and the study of the effect of glycosylation on conformation.
Hollosi, Miklos +3 more
core +1 more source
Cerebrospinal fluid levels of opioid peptides in fibromyalgia and chronic low back pain [PDF]
Background The mechanism(s) of nociceptive dysfunction and potential roles of opioid neurotransmitters are unresolved in the chronic pain syndromes of fibromyalgia and chronic low back pain.
James N Baraniuk +24 more
core +2 more sources
Traditional Chinese herbal formula XuMingZhuSan showed its efficacy in treating stroke. It was capable of attenuating neuronal damage and mitochondrial damage and reducing infarction volume in rats with stroke. Mechanically, XuMingZhuSan might treat stroke by relieving neuronal ferroptosis via activating the NRF2/GPX4/SLC7A11 pathway.
Xi Liu +9 more
wiley +1 more source
The synthesis and characterization of polypeptide-adriamycin conjugates and its complexes with adriamycin. Part I [PDF]
Poly(α-l-glutamic acid) (PGA) was grafted with amino acid and oligopeptide spacers up to 5 amino acids with the use of N,N'-carbonyldiimidazole and 2,3-dihydro-1,2-benz-isothiazole-3-on-1, 1-dioxide (saccharin) as an additive, and these polypeptides were
Eenink, M.J.D. +5 more
core +2 more sources
Thermometer Ions, Internal Energies, and In‐Source Fragmentation in Ambient Ionization
ABSTRACT Ionization and fragmentation are at the core of mass spectrometry. But they are not necessarily separated in space, as in‐source fragmentation can also occur. Here, we survey the literature published since our 2005 review on the internal energy and fragmentation in electrospray ionization sources.
Emilie Bertrand, Valérie Gabelica
wiley +1 more source

