Results 111 to 120 of about 5,668 (135)

Influence of methionine-enkephalin on stress-induced parameters

International Journal of Immunopharmacology, 1998
This study examines the influence of methionine-enkephalin (MENK) on stress-induced oxidative damage (lipid peroxidation; LPO) in mice liver homogenate, plasma corticosterone concentration (CS) and phagocytic activity of mouse splenocytes. The LPO value increased in the mice subjected to restraint stress and had no correlation to stress duration, while
Sabina Rabatić, Tanja Marotti, Višnja Šverko, Ivo Hršak, Boris Ročić   +4 more
openaire   +4 more sources

Plasma Methionine-Enkephalin and Leucine-Enkephalin in Normal Subjects and Patients with Pheochromocytoma*

The Journal of Clinical Endocrinology & Metabolism, 1983
Plasma methionine-enkephalin-like and leucine-enkephalin-like immunoreactivity (met-enkephalin-LI and leu-enkephalin-LI, respectively) in six normal subjects and six patients with pheochromocytoma were determined. The contents of met-enkephalin-LI and leu-enkephalin-LI in two of six pheochromocytomas were 40- to 50-fold higher and those in the other ...
Yoshio Ikeda, Makoto Sakamoto, Takaaki Yoshimasa, Kazuwa Nakao, Shozo Li, Mitsuaki Suda, Hiroo Imura   +6 more
openaire   +3 more sources

Total Synthesis of Methionine‐Enkephalin

Angewandte Chemie International Edition in English, 1976
AbstractIm vas deferens der Maus weist das Titelpeptid (I) eine 20fache und Leucin‐Enkephalin eine 10fache Normorphin‐ Wirkung auf.
Emanuel Pietrzik, Claus Bürvenich, Hans Horn, Wolfgang Voelter, Hubert Kalbacher   +4 more
openaire   +4 more sources

Pharmacodynamics and Biophasic Drug Levels of Methionine Enkephalin

Pharmaceutical Research, 1991
Methionine enkephalin (Met-E) is a naturally occurring pentapeptide. It appears to mediate pain perception by blocking CNS pathways. Using rabbits, a log dose relationship was obtained between Met-E-induced dilation of the pupil (mydriasis) and constant intravenous infusion dose rates (14, 20, 28, 37, 56, 73, and 129 micrograms/min/kg).
Ashim K. Mitra, Lih-Min Her, Randall J. Erb, Anna A. Abdallah   +3 more
openaire   +3 more sources

The paradoxical role of methionine enkephalin in tumor responses

European Journal of Pharmacology, 2020
Methionine enkephalin (MENK) is an opioid peptide composed of five amino acids with multiple biological activities. Since its discovery, MENK has become prominent in neuroregulation and immunoregulation. Tumors have increasingly been a spotlight because of their terrible trends and refractory characteristic.
Cheng Tian, Ming Xiang, Yali Tuo, Lili Lu   +3 more
openaire   +3 more sources

Stabilization of methionine-enkephalin in human and rat blood

Life Sciences, 1986
Methods of preventing the degradation of 3H-methionine-enkephalin (3H-ME) in human blood both at 37 degrees C and under conditions of immediate cooling were examined. We found that, contrary to previous suggestions, use of aprotinin (with or without immediate cooling) was ineffective in preventing the degradation of 3H-ME in blood.
Vincent J. Aloyo, Glen R. Van Loon, Shaker A. Mousa   +2 more
openaire   +3 more sources

Methionine enkephalin metabolism by murine macrophage ectopeptidase(s)

Regulatory Peptides, 1994
Ectopeptidases which hydrolyze opioid and other neuropeptides have been identified in brain, kidney and intestine. In this study, identification of the enzymes metabolizing the opioid peptide methionine enkephalin (YGGFM) in murine macrophages was undertaken.
Louis B. Hersh, Gene L. Cottam, Bonnie C. Miller, Ackroyd A   +3 more
openaire   +3 more sources

Effect of methionine-enkephalin on xanthophore aggregation

Peptides, 1980
The intracranial injection of an opioid antagonist (naloxone) caused aggregation of xanthophores in goldfish scales. This aggregating effect produced by naloxone was inhibited by an injection of methionine-enkephalin (M-ENK). M-ENK, when injected together with melatonin which normally produces aggregation of xanthophores, interfered with the effect of ...
openaire   +3 more sources

Biosynthetic origin and receptor conformation of methionine enkephalin

Nature, 1976
RECENT reports have shown that the brain contains an endogenous peptide with opiate-like activity1–3 and similar peptides have been found in the pituitary4,5,13. One of the brain peptides, known as methionine enkephalin, was identified as a pentapeptide Tyr–Gly–Gly–Phe–Met6, and evidence was presented that a minor component may have leucine in place of
C. R. Snell, Derek G. Smyth, A.F. Bradbury   +2 more
openaire   +3 more sources

Proton Magnetic Resonance Studies of Methionine Enkephalin

Biochemical and Biophysical Research Communications, 1996
In the literature there exist two conflicting pieces of data concerning the thermodynamics of the Cu(2+)-methionine enkephalin complex. One study utilized 1H nuclear magnetic resonance (NMR) to study the solution phase Cu(2+)-enkephalin binding and reported a strong interaction over a wide pH range. Another study utilized potentiometry to measure a log
Peter Tonui, S. S. Toporek, Angela Miller, Dave Powell, Thomas J. Manning   +4 more
openaire   +3 more sources