Results 111 to 120 of about 5,741 (136)
Some of the next articles are maybe not open access.
Stabilization of methionine-enkephalin in human and rat blood
Life Sciences, 1986Methods of preventing the degradation of 3H-methionine-enkephalin (3H-ME) in human blood both at 37 degrees C and under conditions of immediate cooling were examined. We found that, contrary to previous suggestions, use of aprotinin (with or without immediate cooling) was ineffective in preventing the degradation of 3H-ME in blood.
V J, Aloyo, S A, Mousa, G R, Van Loon
openaire +2 more sources
Clinical and Experimental Pharmacology and Physiology, 1989
SUMMARY1. A radio‐immunoassay (RIA) for methionine‐enkephalin sulfoxide was developed and was used to measure methionine‐enkephalin, after oxidation, in the rat brain.2. The RIA was performed together with assays that use commercially available met‐and leu‐enkephalin antisera.3.
G K, Tiong, J E, Olley
openaire +2 more sources
SUMMARY1. A radio‐immunoassay (RIA) for methionine‐enkephalin sulfoxide was developed and was used to measure methionine‐enkephalin, after oxidation, in the rat brain.2. The RIA was performed together with assays that use commercially available met‐and leu‐enkephalin antisera.3.
G K, Tiong, J E, Olley
openaire +2 more sources
Proton Magnetic Resonance Studies of Methionine Enkephalin
Biochemical and Biophysical Research Communications, 1996In the literature there exist two conflicting pieces of data concerning the thermodynamics of the Cu(2+)-methionine enkephalin complex. One study utilized 1H nuclear magnetic resonance (NMR) to study the solution phase Cu(2+)-enkephalin binding and reported a strong interaction over a wide pH range. Another study utilized potentiometry to measure a log
T J, Manning +4 more
openaire +2 more sources
Methionine enkephalin metabolism by murine macrophage ectopeptidase(s)
Regulatory Peptides, 1994Ectopeptidases which hydrolyze opioid and other neuropeptides have been identified in brain, kidney and intestine. In this study, identification of the enzymes metabolizing the opioid peptide methionine enkephalin (YGGFM) in murine macrophages was undertaken.
B C, Miller +3 more
openaire +2 more sources
Biosynthetic origin and receptor conformation of methionine enkephalin
Nature, 1976RECENT reports have shown that the brain contains an endogenous peptide with opiate-like activity1–3 and similar peptides have been found in the pituitary4,5,13. One of the brain peptides, known as methionine enkephalin, was identified as a pentapeptide Tyr–Gly–Gly–Phe–Met6, and evidence was presented that a minor component may have leucine in place of
A F, Bradbury, D G, Smyth, C R, Snell
openaire +2 more sources
Cross tolerance between morphine and methionine-enkephalin
Nature, 1976TOLERANCE and dependence are characteristic symptoms in man during prolonged use of opiates. We have pointed out1 that for an understanding of these phenomena the interaction between endogenous enkephalin and exogenous opiates is of importance. Normally, enkephalin can be assumed to control inhibitory mechanisms determining the rate of neurotransmitter
A A, Waterfield +2 more
openaire +2 more sources
Self-administration of methionine enkephalin into the nucleus accumbens
Pharmacology Biochemistry and Behavior, 1984Microinfusions of the endogenous opiate neurohumor, methionine enkephalin, into the nucleus accumbens initiated a reinforcing stimulus in a dose-related manner. The reinforcing nature of this intracranial self-administration was evaluated with intermittent schedules of reinforcement and a two-lever discrimination procedure.
N E, Goeders, J D, Lane, J E, Smith
openaire +2 more sources
International journal of peptide and protein research, 1980
Biological activities are reported for two different types of analogues of methionine enkephalin. Cyclic analogues, bridged between the amino- and carboxy- terminals of the parent peptide, are inactive. In contrast, significant levels of activity are displayed by linear isosterically modified analogues in which the Tyr1-Gly2 peptide bond is replaced by
D, Hudson, R, Sharpe, M, Szelke
openaire +1 more source
Biological activities are reported for two different types of analogues of methionine enkephalin. Cyclic analogues, bridged between the amino- and carboxy- terminals of the parent peptide, are inactive. In contrast, significant levels of activity are displayed by linear isosterically modified analogues in which the Tyr1-Gly2 peptide bond is replaced by
D, Hudson, R, Sharpe, M, Szelke
openaire +1 more source
Methionine Enkephalin: Clinical Pharmacology
1986Earlier studies indicated that methionine enkephalin infusions (1,000 micrograms) in normal volunteers induced facial flushing, general vasodilation and noisy stomach (borborgymi). Blood pressure and pulse rate were normal in all experiments. Plasma levels of pancreatic polypeptide, somatostatin, T3 and T4, TSH, FSH, PRL, ACTH, and GH were unchanged ...
N. P. Plotnikoff +8 more
openaire +1 more source
Influence of methionine-enkephalin on stress-induced parameters
International Journal of Immunopharmacology, 1998This study examines the influence of methionine-enkephalin (MENK) on stress-induced oxidative damage (lipid peroxidation; LPO) in mice liver homogenate, plasma corticosterone concentration (CS) and phagocytic activity of mouse splenocytes. The LPO value increased in the mice subjected to restraint stress and had no correlation to stress duration, while
Marotti, Tatjana +4 more
openaire +3 more sources