Results 111 to 120 of about 17,087 (287)
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, EarlyView.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Learning Protein Dynamics with Metastable Switching Systems [PDF]
arXiv, 2016 We introduce a machine learning approach for extracting fine-grained representations of protein evolution from molecular dynamics datasets. Metastable switching linear dynamical systems extend standard switching models with a physically-inspired stability constraint.
arxiv
Stochastic dynamics simulations in a new generalized ensemble [PDF]
, 1998 We develop a formulation for molecular dynamics, Langevin, and hybrid Monte Carlo algorithms in the recently proposed generalized ensemble that is based on a physically motivated realisation of Tsallis weights. The effectiveness of the methods are tested with an energy function for a protein system. Simulations in this generalized ensemble by the three
arxiv +1 more source
, 1997 Opioid peptides produced in the body act as neuromodulators that modify the actions of other neurotransmitters in the central nervous system. By altering the electrical properties of their target neurons, thereby making these neurons more difficult to ...
Froehlilch, Janice C.
core
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose We previously showed that the iridoid glycoside extract of Lamiophlomis rotata (IGLR) induces M2 macrophage polarisation to accelerate wound healing. The potentially active compounds (quality markers) in IGLR that accelerate wound healing have not been elucidated; we here identified quality markers that accelerate wound ...
Huan Li +7 more
wiley +1 more source
PLoS ONE, 2019 Dipeptidyl amino-peptidase 3 (DPP3) is an aminopeptidase involved in peptide degradation, including hormone peptides as angiotensin II and enkephalins. DPP3 plasma activity increases in septic patients and correlates with mortality risk.
Paul Kaufmann +7 more
doaj +1 more source
Naloxone inhibits and morphine potentiates. The adrenal steroidogenic response to ACTH [PDF]
The adrenal actions were stereospecific since neither the positve stereoisomer of morphine, nor that of naloxone, had any effect on the adrenal response to exogenous adrenocorticotrophic hormone (ACTH).
Heybach, J. P., Vernikos, J.
core +1 more source
Electroacupuncture as a treatment for suspected trigeminal nerve‐mediated head‐shaking in 42 horses
Equine Veterinary Education, EarlyView.Summary Background Electroacupuncture (EA) has been used successfully as a treatment for trigeminal nerve‐mediated head‐shaking (TMHS) in a small case series, but results from a larger number of cases are lacking. Objectives To retrospectively investigate the effectiveness of EA as a treatment for horses with TMHS.
B. Dunkel +5 more
wiley +1 more source
Single‐cell genomics meets systems neuroscience: Insights from mapping the brain circuitry of stress
Journal of Neuroendocrinology, EarlyView.Abstract Responses to external and internal dangers is essential for survival and homeostatic regulation. Hypothalamic corticotropin‐releasing hormone neurons (CRHNs) play a pivotal role in regulating neuroendocrine responses to fear and stress.
Naresh K. Hanchate
wiley +1 more source
The human colon: Evidence for degenerative changes during aging and the physiological consequences
Neurogastroenterology &Motility, EarlyView.Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source