The Evolutionary Biology of Female‐Biased Pain and Its Disorders
Evolutionary Applications, Volume 19, Issue 4, April 2026.ABSTRACT This article describes and evaluates a general evolutionary theory for explaining variation among individuals in sensitivity to pain, the Vulnerability‐Value‐Opportunity model. The model posits that pain sensitivity is mediated by vulnerability to fitness‐reducing injury (probabilities of damage, including from infection), Fisherian ...
Bernard Crespi
wiley +1 more source
Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]
, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér +6 more
core +2 more sources
The role of enkephalins in the perioperative period in patients with oropharyngeal cancer
Сибирский онкологический журналPostoperative metabolic disorder, namely the development of protein-energy deficiency is one of the challenges in cancer surgery, especially in head and neck surgeries, which are considered the most traumatic. The development of protein-energy deficiency
D. N. Vasiliev +7 more
doaj +1 more source
Receptors of peptides as therapeutic targets in epilepsy research [PDF]
, 2014 Neuropeptides are signaling molecules participating in the modulation of synaptic transmission. Neuropeptides are stored in dense core synaptic vesicles, the release of which requires profound excitation.
Dobolyi, A. +5 more
core +1 more source
NEUROTROPHIC EFFECTS OF ETIFOXINE
Неврология, нейропсихиатрия, психосоматика, 2016 Higher anxiety results in the decreased levels of various neurotrophic factors and enkephalins and in impaired production of proinflammatory cytokines. The anxiolytic etifoxine is used to treat anxiety states and adjustment disorders. Etifoxine modulates
I. Yu. Torshin +4 more
doaj +1 more source
Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]
, 2012 Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Baseer, N. +5 more
core +1 more source
Nicotine Effects and the Endogenous Opioid System
Journal of Pharmacological Sciences, 2014 .: Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins,
Shiroh Kishioka +3 more
doaj +1 more source
Proenkephalin, neutrophil gelatinase-associated lipocalin, and estimated glomerular filtration rates in patients with sepsis [PDF]
, 2017 Background: Proenkephalin (PENK) has been suggested as a novel biomarker for kidney function. We investigated the diagnostic and prognostic utility of plasma PENK in comparison with neutrophil gelatinase-associated lipocalin (NGAL) and estimated ...
Andreas Bergmann +10 more
core +1 more source
Frontiers in PharmacologyNeprilysin (NEP), a zinc-dependent membrane-bound metallopeptidase, regulates various bioactive peptides, particularly in kidneys, vascular endothelium, and the central nervous system.
Xinyue Zhang +5 more
doaj +1 more source
Activité analgésique des lymphocytes T CD4+ effecteurs générés au cours de la réponse immunitaire adaptative [PDF]
, 2012 La sensation douloureuse est une caractéristique de la réponse inflammatoire qui accompagne les infections par des pathogènes ou les lésions tissulaires.
Boué, Jérôme
core