Results 81 to 90 of about 10,153 (221)

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

open access: yesComprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu   +11 more
wiley   +1 more source

Molecular Aspect of Annelid Neuroendocrine system

open access: yes, 2007
Hormonal processes along with enzymatic processing similar to that found in vertebrates occur in annelids. Amino acid sequence determination of annelids precursor gene products reveals the presence of the respective peptides that exhibit high sequence ...
Salzet, M.
core   +1 more source

Using FoxP2 to Distinguish Direct and Indirect Basal Ganglia Pathways for Vocal Learning in Songbirds

open access: yesDevelopmental Neurobiology, Volume 86, Issue 2, April 2026.
ABSTRACT The cortico‐basal ganglia pathways that mediate vocal learning in zebra finches (Taeniopygia guttata) are localized in parallel circuits formed by CORE and SHELL subregions. These circuits traverse a specialized region of the basal ganglia essential for vocal learning (Area X), which includes intermixed striatal and pallidal neurons.
Aditi Jagannathan   +2 more
wiley   +1 more source

The Medicalization of Cannabis [PDF]

open access: yes, 2010
Annotated and edited transcript of a Witness Seminar held on 24 March 2009. Introduction by Professor Leslie Iversen.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2010.©The Trustee of the Wellcome Trust, London, 2010 ...
Crowther, SM, Reynolds, LA, Tansey, EM
core  

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

open access: yesMedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai   +3 more
wiley   +1 more source

Optimization of Hot and Cold‐Water Extractions of Cistus salviifolius L. for Enhanced Phenolic Content and Antimicrobial Efficacy

open access: yesChemistrySelect, Volume 11, Issue 13, 6 April 2026.
This study optimized cold and hot water extractions for maximizing phenolic content and antibacterial activity against S. aureus and P. aeruginosa. Hot water yielded higher total phenolics and were more effective against P. aeruginosa. Conversely, cold water enriched specific ellagitannins (punicalagin and cistusin), showing potent, targeted ...
Atalanti Christou   +9 more
wiley   +1 more source

Evaluation of Analgesic Activity of Newly Synthesized Phthalyl- tyrosyl-glycin Sodium

open access: yesIraqi Journal of Pharmaceutical Sciences, 2017
Alteration in the backbone structure of the endogenously released opioid peptides Leu5/Met5 enkephalins may result in compounds having comparable profile of pharmacological activity but with different physicochemical properties and side effects. Phthalyl
Muthanna S. AL-Taee   +2 more
doaj   +3 more sources

A novel and highly efficient purification procedure for native human dipeptidyl peptidase 3 from human blood cell lysate.

open access: yesPLoS ONE, 2019
Dipeptidyl amino-peptidase 3 (DPP3) is an aminopeptidase involved in peptide degradation, including hormone peptides as angiotensin II and enkephalins. DPP3 plasma activity increases in septic patients and correlates with mortality risk.
Paul Kaufmann   +7 more
doaj   +1 more source

A comprehensive review of the pharmacodynamics, pharmacokinetics and clinical effects of the neutral endopeptidase inhibitor racecadotril

open access: yesFrontiers in Pharmacology, 2012
Racecadotril, via its active metabolite thiorphan, is an inhibitor of the enzyme neutral endopeptidase (NEP, EC 3.4.24.11), thereby increasing exposure to NEP including enkephalins and atrial natriuretic peptide.
Marion eEberlin   +2 more
doaj   +1 more source

Prosocial Behavior as a Stress Moderator: The Physiological and Psychological Components [PDF]

open access: yes, 2018
Stress is a major part of everyday life for the majority of people, especially college students. Stress has a physiological response and serves an important purpose in the body.
Vannelli, Jessica
core   +1 more source

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